Results 1 to 10 of about 6,130 (194)

Cell-Specific Vulnerability of Human Glioblastoma and Astrocytoma Cells to Mephedrone—An In Vitro Study [PDF]

Molecules
Glioblastoma multiforme is a highly aggressive intrinsic brain tumor with a very poor survival rate. The main treatment for cancer is surgery combined with postoperative radiotherapy and temozolomide chemotherapy.
Marta Marszalek-Grabska, Marta Kinga Lemieszek, Michal Chojnacki, Sylwia Winiarczyk, Joanna Jakubowicz-Gil, Barbara Zarzyka, Jarosław Pawelec, Jolanta H. Kotlinska, Wojciech Rzeski, Waldemar A. Turski   +9 more
doaj   +3 more sources

The effect of mephedrone on human neuroblastoma and astrocytoma cells [PDF]

Saudi Pharmaceutical Journal
Mephedrone is an illegal drug that is used recreationally. Few studies have been conducted to investigate the mechanisms by which mephedrone is harming cells.
Ibrahim M. Alanazi, Abdullah R. Alzahrani, Mohammad A. Alsaad, Abdulaziz L. Moqeem, Abdulmohsen M. Hamdi, Mohiuddin M. Taher, David G. Watson, M. Helen Grant   +7 more
doaj   +3 more sources

Mephedrone and Alcohol Interactions in Humans

Frontiers in Pharmacology, 2020
Mephedrone (4-MMC, mephedrone) is a synthetic cathinone derivative included in the class of new psychoactive substances. It is commonly used simultaneously with alcohol (ethanol).
Clara Pérez-Mañá, Eulalia Olesti, Kim P C Kuypers   +2 more
exaly   +4 more sources

Mephedrone – a synthetic derivative of cathinone

Current Issues in Pharmacy and Medical Sciences, 2023
Novel psychoactive substances (NPS) are a very diverse group of recreational drugs that mimic effects of classic drugs of abuse and, at least at the beginning, are not usually prohibited.
Bielecka-Papierz Gabriela, Poleszak Ewa, Serafko Anna   +2 more
doaj   +2 more sources

The role of the L-arginine-NO-cGMP pathway in the development of tolerance to mephedrone-induced hyperlocomotion in mice

Current Issues in Pharmacy and Medical Sciences, 2023
The tendency of a psychostimulant to increase locomotion in rodents is considered to be associated with its addictive properties. Mephedrone, one of the most popular psychoactive substances used recreationally, is known to enhance locomotor activity in ...
Bielecka-Papierz Gabriela, Poleszak Ewa, Szopa Aleksandra, Listos Joanna, Orzelska-Gorka Jolanta, Jakobczuk Małgorzata, Baluk Kamila, Talarek Sylwia, Serefko Anna   +8 more
doaj   +2 more sources

Central Effects of the Designer Drug Mephedrone in Mice—Basic Studies

Brain Sciences, 2022
Mephedrone belongs to the “party drugs” thanks to its psychostimulant effects, similar to the ones observed after amphetamines. Though mephedrone is used worldwide by humans and in laboratory animals, not all properties of this drug have been discovered ...
Anna Serefko, Gabriela Bielecka-Papierz, Sylwia Talarek, Aleksandra Szopa, Piotr Skałecki, Bernadeta Szewczyk, Maria Radziwoń-Zaleska, Ewa Poleszak   +7 more
doaj   +2 more sources

Mephedrone and Its Metabolites: A Narrative Review. [PDF]

Int J Mol Sci
New psychoactive substances (NPSs) have emerged as a significant global public health challenge due to their ability to mimic traditional drugs. Among these, mephedrone has gained attention because of its widespread use and associated toxicities.
Michal O, Daria T, Izabela J, Gorecka W, Tadeusz N, Elzbieta M, Magdanena BZ.   +6 more
europepmc   +2 more sources

Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity in vitro

Frontiers in Pharmacology, 2021
Mephedrone is a largely abused psychostimulant. It elicits the release of monoamines via the high affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT).
Marco Niello, Daniela Cintulová, Philip Raithmayr, Marion Holy, Kathrin Jäntsch, Claire Colas, Gerhard F. Ecker, Harald H. Sitte, Marko D. Mihovilovic   +8 more
doaj   +2 more sources

Acute Pharmacological Effects of Oral and Intranasal Mephedrone: An Observational Study in Humans

Pharmaceuticals, 2021
Mephedrone (4-methylmethcathinone) is a synthetic cathinone with psychostimulant properties which remains one of the most popular new psychoactive substances (NPS). It is frequently used orally and/or intranasally.
Esther Papaseit, Eulalia Olesti, Clara Pérez-Mañá, Marta Torrens, Francina Fonseca, Marc Grifell, Mireia Ventura, Rafael de la Torre, Magí Farré   +8 more
doaj   +2 more sources

Development of an Electrochemical Sensor Using a Modified Carbon Paste Electrode with Silver Nanoparticles Capped with Saffron for Monitoring Mephedrone

Sensors, 2022
Mephedrone, also known as 4-methylmethcathinone, is growing into a prominent recreational drug for young people. When it came to detecting mephedrone, limited efforts were made using electrochemical sensors.
Georgios Christos Papaioannou, Sophia Karastogianni, Stella Girousi   +2 more
doaj   +2 more sources