Results 51 to 60 of about 221,928 (269)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Several applications of capillary electrophoresis for wines analysis. Quantitation of organic and inorganic acids, inorganic cations, amino acids and biogenic amines

OENO One, 1997
Capillary electrophoresis is now a well known analytical mean for the analysis of a great number of different molecules in miscellaneous media. Its usefullness is relatively unknown in oenology.
Michel Arellano, N. Siméon, Ph. Puig, François Couderc   +3 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Synthesis, molecular and crystal structure of [(NH2)2CSSC(NH2)2]2[RuBr6]Br2·3H2O

Acta Crystallographica Section E: Crystallographic Communications
The title compound, bis[dithiobis(formamidinium)] hexabromidoruthenium dibromide trihydrate, [(NH2)2CSSC(NH2)2]2[RuBr6]Br2·3H2O, crystallizes in the orthorhombic system, space group Cmcm, Z = 4.
Olga V. Rudnitskaya, Milena R. Komarovskikh, Maria G. Pekarskaya, Daniil S. Pshenichnyy, Mehmet Akkurt, Ali N. Khalilov, Ajaya Bhattarai, Ibrahim G. Mamedov   +7 more
doaj   +1 more source

THE NATURAL WATERS’ QUALITY ASSESSMENT AT THE YAMALO-NENETSK AUTONOMOUS DISTRICT SCIENTIFIC GROUNDS (PUROVSKIY, TAZOVSKIY, SHURYSHKARSKIY, POLYARNO-URALSKIY)

Водное хозяйство России: проблемы, технологии, управление, 2019
Surface water bodies are most vulnerable to chemical pollution. Objective: to study the hydro/chemical indicators of the state of surface waters of the Yamalo-NenetskAutonomous District and to assess their quality.
Yelena V. Agbalyan, Roman A. Kolesnikov, Aleksandr S.Krasnenko, Yevgenia N. Morgun, Yelena V. Shinkaruk, Aleksandr S. Pechkin, Rostislav I. Loktev, Ruslan M. Ilyasov, Vasiliy O. Kobelev   +8 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Response to “The Enduring Association of a First Pregnancy Abortion With Subsequent Pregnancy Outcomes: A Longitudinal Cohort Study”

Health Services Research & Managerial Epidemiology, 2023
Monica Cations, Judith Dwyer
doaj   +1 more source

Surface cellulose modification with 2-aminomethylpyridine for copper, cobalt, nickel and zinc removal from aqueous solution

Materials Research, 2013
Cellulose was first modified with thionyl chloride, followed by reaction with 2-aminomethylpyridine to yield 6-(2'-aminomethylpyridine)-6-deoxycellulose.
Edson Cavalcanti Silva Filho, Luiz Sousa Santos Júnior, Marcia Maria Fernandes Silva, Maria Gardênnia Fonseca, Sirlane Aparecida Abreu Santana, Claudio Airoldi   +5 more
doaj