Results 61 to 70 of about 233,535 (219)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Applied SciencesSeveral experimental studies have shown that clinoptilolite zeolite is a suitable candidate for the adsorption of pharmaceuticals and related compounds. However, there is a significant lack of detailed molecular-level insights regarding how the adsorbed ...
Lobna Saeed, Michael Fischer
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Oligonucleotide analogues with cationic backbone linkages
Beilstein Journal of Organic Chemistry, 2018 Their unique ability to selectively bind specific nucleic acid sequences makes oligonucleotides promising bioactive agents. However, modifications of the nucleic acid structure are an essential prerequisite for their application in vivo or even in ...
Melissa Meng, Christian Ducho
doaj +1 more source
Ciência Rural, 2010 Com o objetivo de avaliar o efeito de doses de potássio fornecido pela fertirrigação e de cálcio na parte aérea sobre o crescimento da planta, a produção e a qualidade de frutas do morangueiro em cultivo sem solo, plantas de morangueiro foram cultivadas ...
Jerônimo Luiz Andriolo +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Could Life Have Started on Mars? Planetary Conditions That Assemble and Destroy Protocells
LifeEarly Mars was likely habitable, but could life actually have started there? While cellular life emerged from prebiotic chemistry through a pre-Darwinian selection process relevant to both Earth and Mars, each planet posed unique selection ‘hurdles’ to ...
Francesca C. A. Cary +5 more
doaj +1 more source
Cold tolerance, water relations and accumulation of osmolytes in Bituminaria bituminosa
Biologia Plantarum, 2010 We determined the cold (freezing) tolerance of five Spanish populations of the perennial shrub Bituminaria bituminosa (L.) C.H. Stirton (Fabaceae), as the temperature at which 50 % of leaf electrolytes are released (LT50) using leaves of field-grown ...
D. J. Walker, P. Romero, E. Correal
doaj +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Soil and Water ResearchSoil salinity is a growing problem for agricultural production in irrigated areas of arid and semi-arid regions. The extent of salinity levels has not been fully studied in the Kesem irrigation scheme in Ethiopia's Afar region. The objective of the study
Mengistu Jiru +3 more
doaj +1 more source