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CatSper Calcium Channels: 20 Years On
Physiology, 2023The flagellar-specific Ca2+channel CatSper is the predominant Ca2+entry site in mammalian sperm. CatSper-mediated Ca2+signaling affects nearly every event that regulates sperm to acquire fertilizing capability. In this review, we summarize some of the main findings from 20 years of CatSper research and highlight recent progress and prospects.
Jae Yeon Hwang, Jean-Ju Chung
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CatSper channel, sperm function and male fertility [PDF]
Reproductive BioMedicine Online, 2015 A number of physiological events, such as sperm hyperactivation, chemotaxis towards the egg, capacitation and acrosome reaction, are triggered by activation of sperm ion channels in response to a diverse range of chemical cues. Cation channel of sperm (CatSper), a sperm-specific ion channel, is unique in orchestrating the events for fertilization, and ...
Singh Rajender
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Down-regulation of CatSper 1 and CatSper 2 genes by methamphetamine
Toxin Reviews, 2021Methamphetamine (METH) is a strong central nervous system stimulant that has toxic effects on the reproductive system.
Somaieh Mansouri +3 more
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CatSper channels in sea urchin sperm
Cell Calcium, 2021Sea urchin sperm swimming is regulated by speract, a decapeptide released from egg jelly that induces chemotaxis and triggers membrane potential (Em) changes, intracellular increases in cyclic nucleotides (cGMP, cAMP), pH (pHi) and calcium concentration ([Ca2+]i).
Verónica, Loyo-Celis +3 more
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The CatSper channel modulates boar sperm motility during capacitation
Reproductive Biology, 2017 The cation channel of sperm (CatSper) comprises four transmembrane subunits specifically expressed in human, equine, murine and ovine spermatozoa, apparently implicated in capacitation, hyperactivation and acrosome exocytosis. Western blotting and immunocytochemistry showed hereby that CatSper subunits are also present in boar spermatozoa, primarily ...
Alejandro Vicente-Carrillo +2 more
exaly +5 more sources
Sperm CatSper ion channel swims into sharper focus
Nature, 2021Activation of the CatSper membrane ion channel triggers enhanced sperm motility, and this protein complex is required for male fertility. Structural data now provide insights into the channel, and offer a few surprises, too. Cryo-EM data sheds light on a protein complex needed for male fertility.
David E Clapham, Raymond E Hulse
exaly +2 more sources
Genetic male infertility and mutation of CATSPER ion channels [PDF]
European Journal of Human Genetics, 2010 A clinically significant proportion of couples experience difficulty in conceiving a child. In about half of these cases male infertility is the cause and often genetic factors are involved. Despite advances in clinical diagnostics ∼50% of male infertility cases remain idiopathic.
Yuzhou Zhang +2 more
exaly +3 more sources
Calcium Signaling Through CatSper Channels in Mammalian Fertilization
Physiology, 2010The molecular mechanisms underlying Ca2+entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility.
Dejian, Ren, Jingsheng, Xia
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Finasteride interferes with prostaglandin-induced CatSper signalling in human sperm
Reproduction, 2021Ca2+ signalling controls human sperm functions necessary for successful fertilization. Multiple endocrine-disrupting chemicals have been found to activate the CatSper Ca2+ channel and thereby interfering with Ca2+ signalling in human sperm. Finasteride is prescribed to men in the fertile age to treat hair loss and its use has been associated with ...
Michala Rosa Birch +3 more
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Science's STKE, 2001
Sperm undergo a process called capacitance, part of which involves increasing their motility in the female reproductive tract. Ren et al. have found and characterized a new Ca 2+ channel expressed in sperm tails, termed CatSper, that is required for sperm motility and male fertility. CatSper
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Sperm undergo a process called capacitance, part of which involves increasing their motility in the female reproductive tract. Ren et al. have found and characterized a new Ca 2+ channel expressed in sperm tails, termed CatSper, that is required for sperm motility and male fertility. CatSper
openaire +2 more sources