Results 111 to 120 of about 560,868 (267)

Policy evaluation of waste pricing programs using heterogeneous causal effect estimation [PDF]

, 2020
Marica Valente
openalex   +1 more source

Sensitivity analysis for unobserved confounding in causal mediation analysis allowing for effect modification, censoring and truncation [PDF]

, 2021
Anita Lindmark
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Effects of bisphosphonates after denosumab discontinuation and treatment effect heterogeneity using causal machine learning [PDF]

Miryoung Kim, Nakyung Jeon, Hae Sun Suh
openalex   +1 more source

Unbiased Learning for the Causal Effect of Recommendation [PDF]

, 2020
Masahiro Sato, Sho Takemori, Janmajay Singh, Tomoko Ohkuma   +3 more
openalex   +1 more source

A mixed model approach to estimate the survivor average causal effect in cluster‐randomized trials [PDF]

, 2023
Wei Wang, Guangyu Tong, Shashivadan P. Hirani, Stanton Newman, Scott D. Halpern, Dylan S. Small, Fan Li, Michael O. Harhay   +7 more
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Causal effects of gut microbiota on multiple sclerosis: A two‐sample Mendelian randomization study

Brain and Behavior
Background Gut microbiota alterations in multiple sclerosis (MS) patients have been reported in observational studies, but whether these associations are causal is unclear.
Dongren Sun, Yangyang Zhang, Rui Wang, Qin Du, Ziyan Shi, Hongxi Chen, Xiaofei Wang, Hongyu Zhou   +7 more
doaj   +1 more source

The Effect of Family Wealth on Physical Function Among Older Adults in Mpumalanga, South Africa: A Causal Network Analysis [PDF]

, 2023
Keletso Makofane, Lisa Berkman, Mary T. Bassett, Eric J. Tchetgen Tchetgen   +3 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source