Results 121 to 130 of about 15,686,088 (395)

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Using Causal Effect Networks to Analyze Different Arctic Drivers of Midlatitude Winter Circulation

, 2016
In recent years, the Northern Hemisphere midlatitudes have suffered from severe winters like the extreme 2012/13 winter in the eastern United States.
M. Kretschmer, D. Coumou, J. Donges, Jakob Runge   +3 more
semanticscholar   +1 more source

Evidence of a Causal Effect of Estradiol on Fracture Risk in Men

Journal of Clinical Endocrinology and Metabolism, 2018
Context Observational studies indicate that serum estradiol (E2) is more strongly associated with bone mineral density (BMD) than serum testosterone (T) is, whereas both E2 and T associate with fracture risk in men.
M. Nethander, L. Vandenput, A. Eriksson, S. Windahl, T. Funck‐Brentano, C. Ohlsson   +5 more
semanticscholar   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Background Plasminogen activator inhibitor type 1 (PAI‐1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI‐1 levels are associated with increased risk of coronary heart disease (CHD ...
Ci Song, S. Burgess, J. Eicher, C. O’Donnell, Jie Huang, M. Sabater-Lleal, F. Asselbergs, D. Tregouet, So-Youn Shin, Jingzhong Ding, Tiphaine Oudot-Mellakh, L. Folkersen, Scott M. Williams, M. Ikram, M. Kleber, D. Becker, V. Truong, J. Mychaleckyj, Weihong Tang, Qiong Yang, B. Sennblad, J. Moore, F. Williams, G. Silbernagel, E. Schrijvers, Shelly G. Smith, M. Karakas, G. Tofler, A. Silveira, G. Navis, K. Lohman, A. Peters, P. Lundmark, R. Strawbridge, B. Boehm, A. Carter, B. McKnight, J. Öhrvik, M. Franzosi, U. Seedorf, R. Collins, A. Franco-Cereceda, A. Syvänen, A. Goodall, L. Yanek, M. Cushman, M. Müller-Nurasyid, A. Folsom, S. Basu, N. Matijevic, J. Meigs, B. Winkelmann, P. Grant, H. Hillege, T. Spector, L. Becker, R. Tracy, W. März, P. Eriksson, F. Cambien, P. Morange, G. Ehret, P. Munroe, K. Rice, M. Bochud, D. Chasman, M. Tobin, G. Verwoert, Vasyl Pihur, P. Vollenweider, P. O’Reilly, N. Amin, J. Bragg-Gresham, A. Teumer, L. Launer, Jing Hua Zhao, Y. Aulchenko, S. Heath, S. Sõber, J. Luan, P. Arora, Feng Zhang, G. Lucas, A. Hicks, A. Jackson, J. Peden, Toshiko Tanaka, S. Wild, I. Rudan, W. Igl, Y. Milaneschi, A. Parker, C. Fava, J. Chambers, E. Fox, M. Kumari, M. Go, P. van der Harst, W. Kao, M. Sjögren, D. Vinay, M. Alexander, Y. Tabara, S. Shaw-Hawkins, P. Whincup, Gang Shi, J. Kuusisto, B. Tayo, Mark Seielstad, X. Sim, Khanh-dung Nguyen, G. Matullo, Ying Wu, Tom R. Gaunt, N. Onland-Moret, M. Cooper, Carl G. P. Platou, E. Org, R. Hardy, Santosh Dahgam, J. Palmen, V. Vitart, P. Braund, T. Kuznetsova, C. Uiterwaal, A. Adeyemo, W. Palmas, H. Campbell, B. Ludwig, M. Tomaszewski, I. Tzoulaki, Nicholette D. Palmer, M. Garcia, Y. C. Chang, N. Steinle, D. Grobbee, D. Arking, S. Kardia, A. Morrison, D. Hernandez, S. Najjar, W. McArdle, D. Hadley, Morris J. Brown, J. Connell, A. Hingorani, I. Day, D. Lawlor, J. Beilby, R. Lawrence, R. Clarke, J. Hopewell, H. Ongen, A. Dreisbach, Yali Li, J. H. Young, L. Adair, N. Lee, Ming-Huei Chen, M. Olden, C. Pattaro, Judith A. Hoffman Bolton, A. Köttgen, S. Bergmann, V. Mooser, N. Chaturvedi, T. Frayling, Muhammad Islam, T. Jafar, J. Erdmann, S. R. Kulkarni, S. Bornstein, J. Grässler, L. Groop, J. Kettunen, Philip N. Howard, Andrew W. Taylor, S. Guarrera, F. Ricceri, V. Emilsson, A. Plump, I. Barroso, K. Khaw, A. Weder, S. Hunt, R. Bergman, F. Collins, L. Bonnycastle, L. Scott, H. Stringham, M. Perola, E. Vartiainen, S. Brand, J. Staessen, Thomas J. Wang, P. Burton, M. Artigas, Yanbin Dong, H. Snieder, Xiaoling Wang, Haidong Zhu, K. Lohman, Megan E. Rudock, N. Smith, K. Wiggins, A. Doumatey, Daniel Shriner, G. Veldre, M. Viigimaa, S. Kinra, D. Prabhakaran, V. Tripathy, C. Langefeld, A. Rosengren, D. Thelle, A. Corsi, A. Singleton, T. Forrester, G. Hilton, C. McKenzie, T. Salako, N. Iwai, Y. Kita, T. Ogihara, T. Ohkubo, T. Okamura, H. Ueshima, S. Umemura, S. Eyheramendy, T. Meitinger, H. Wichmann, Y. Cho, Hyung-Lae Kim, Jong-Young Lee, J. Scott, J. Sehmi, Weihua Zhang, B. Hedblad, P. Nilsson, G. Smith, A. Wong, Narisu Narisu, A. Stančáková, L. Raffel, Jie Yao, M. Arfan Ikram, W. Longstreth, T. Mosley, S. Seshadri, N. Shrine, L. Wain, M. Morken, A. Swift, J. Laitinen, I. Prokopenko, P. Zitting, J. Cooper, S. Humphries, J. Danesh, A. Rasheed, A. Goel, A. Hamsten, H. Watkins, S. Bakker, W. V. van Gilst, C. S. Janipalli, K. R. Mani, C. Yajnik, F. Mattace-Raso, B. Oostra, A. Demirkan, M. Ala-Korpela, A. Kangas, L. Lyytikäinen, P. Soininen, T. Tukiainen, P. Würtz, R. Ong, H. Kroemer, U. Völker, P. Galan, S. Hercberg, M. Lathrop, D. Zélénika, P. Deloukas, M. Mangino, T. Spector, G. Zhai, J. Meschia, M. Nalls, Pankaj Sharma, J. Terzic, M. V. Kranthi Kumar, M. Denniff, E. Zukowska-szczechowska, L. Wagenknecht, F. Fowkes, F. Charchar, P. Schwarz, Xiuqing Guo, C. Rotimi, M. Bots, E. Brand, N. Samani, O. Polašek, P. Talmud, F. Nyberg, D. Kuh, M. Laan, K. Hveem, L. Palmer, Y. T. van der Schouw, J. Casas, K. Mohlke, P. Vineis, S. Ganesh, T. Wong, E. Tai, R. Cooper, M. Laakso, D. Rao, R. Morris, A. Dominiczak, M. Kivimaki, M. Marmot, T. Miki, D. Saleheen, G. Chandak, J. Coresh, G. Navis, B. Han, Xiaofeng Zhu, J. Kooner, O. Melander, P. Ridker, S. Bandinelli, U. Gyllensten, A. Wright, L. Ferrucci, M. Farrall, J. Tuomilehto, P. Pramstaller, N. Soranzo, E. Sijbrands, R. Loos, C. Gieger, P. Meneton, N. Wareham, R. Rettig, D. Strachan, J. Witteman, A. Hartikainen, J. Beckmann, R. Vasan, M. Boehnke, M. Larson, M. Järvelin, A. Chakravarti, P. Elliott, C. V. van Duijn, C. Newton‐Cheh, D. Levy, M. Caulfield, T. Johnson, A. van der Lugt, A. Isaacs, A. Dehghan, A. Parsa, A. Shuldiner, A. Hofman, A. Smith, A. Kraja, A. Uitterlinden, A. Uitterlinden, A. Ziegler, Andrew D. Johnson, A. Scuteri, A. Newman, A. Schillert, B. Voight, B. Oostra, B. Thórsson, B. Mitchell, B. Psaty, C. Hayward, C. Fox, Charles White, C. Meisinger, C. Ballantyne, C. V. van Duijn, D. Altshuler, D. Herrington, D. O'leary, D. Siscovick, D. Couper, E. Lakatta, E. Halperin, E. Boerwinkle, Eva‐Maria Stoegerer, F. Rivadeneira, F. Ernst, G. Krestin, G. Homuth, G. Heiss, G. Usala, G. Abecasis, G. Eiriksdottir, Haiqing Shen, H. Wichmann, H. Schmidt, H. Völzke, I. Borecki, H. Markus, J. Witteman, James F. Wilson, J. Lüdemann, J. O’Connell, J. Huffman, J. Baumert, J. Rotter, J. Murabito, J. Thiery, J. Seissler, J. Viikari, J. Massaro, J. Polak, J. Cunningham, J. Bis, K. North, K. Petrovic, K. Rice, K. Taylor, L. Cupples, L. Bielak, L. Peltonen, L. Launer, M. de Andrade, M. Uda, M. Orrù, M. Dörr, M. Feitosa, M. Kavousi, M. Sitzer, M. Oudkerk, M. Province, M. Nalls, M. Kähönen, M. Reilly, N. Glazer, N. Franceschini, N. Klopp, O. Raitakari, P. Peyser, P. Wolf, Qunyuan Zhang, P. Wild, R. Elosúa, R. D'Agostino, R. K. Chilukoti, R. Schmidt, R. Schnabel, S. Kathiresan, S. Sanna, S. Kardia, Shih-Jen Hwang, S. Demissie, S. Sigurdsson, S. Schwartz, S. Blankenberg, S. Bevan, S. Elias-Smale, S. Heckbert, T. Harris, T. Zeller, T. Lehtimäki, T. Illig, T. Münzel, T. Aspelund, T. Howard, U. Hoffmann, U. Schminke, V. Salomaa, Vijay Nambi, V. Gudnason, Yongmei Liu, Yan V. Sun, W. Post, W. Koenig, W. Rathmann, Xia Li, Yuching Cheng   +490 more
semanticscholar   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Directed causal effect with PCMCI in hyperscanning EEG time series

Frontiers in Neuroscience
Social activities are likely to cause effects or reactivity in the brains of the people involved in collaborative social situations. This study assesses a new method, Tigramite, for time domain analysis of directed causality between the prefrontal cortex
Lykke Silfwerbrand, Lykke Silfwerbrand, Yasuharu Koike, Pär Nyström, Malin Gingnell, Malin Gingnell   +5 more
doaj   +1 more source

Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk

Neurology: Genetics, 2016
Objective: We sought to estimate the causal effect of low serum 25(OH)D on multiple sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or subject to reverse causality. Methods: We conducted mendelian randomization (
BS Brooke Rhead, MD Maria Bäärnhielm, M. Gianfrancesco, Mph Amanda Mok, MA Xiaorong Shao, BA Hong Quach, PhD Ling Shen, PhD Catherine Schaefer, PhD Jenny Link, A. Gyllenberg, A. Hedström, PhD Tomas Olsson, PhD Jan Hillert, PhD Ingrid Kockum, ScD M. Maria Glymour, PhD Lars Alfredsson, PhD Lisa F. Barcellos, Karolinska Institutet, Sweden Stockholm, Kaiser   +19 more
semanticscholar   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

Identification and Estimation of Causal Mechanisms and Net Effects of a Treatment under Unconfoundedness [PDF]

An important goal when analyzing the causal effect of a treatment on an outcome is to understand the mechanisms through which the treatment causally works.
Flores, Carlos A., Flores-Lagunes, Alfonso   +1 more
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