Results 41 to 50 of about 687,701 (312)

The association of maternal smoking around birth with chronic respiratory diseases in adult offspring: A Mendelian randomization study

Tobacco Induced Diseases
Introduction Maternal smoking during pregnancy disturbs fetal lung development, and induces in their offspring childhood respiratory diseases. Whether it has a continued impact on offspring adult lung health and exerts a casual effect of chronic ...
Yun-Xia Huo, Xiao-Jun Wang, Wei-Dong Hu, Chaoyan Yue   +3 more
doaj   +1 more source

Information Bottleneck for Estimating Treatment Effects with Systematically Missing Covariates

Entropy, 2020
Estimating the effects of an intervention from high-dimensional observational data is a challenging problem due to the existence of confounding. The task is often further complicated in healthcare applications where a set of observations may be entirely ...
Sonali Parbhoo, Mario Wieser, Aleksander Wieczorek, Volker Roth   +3 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Association between sleep-related phenotypes and gut microbiota: a two-sample bidirectional Mendelian randomization study

Frontiers in Microbiology
BackgroundAn increasing body of evidence suggests a profound interrelation between the microbiome and sleep-related concerns. Nevertheless, current observational studies can merely establish their correlation, leaving causality unexplored.Study ...
Xiaoqiu Wang, Chi Wang, Kai Liu, Qingyun Wan, Wenzhong Wu, Chengyong Liu   +5 more
doaj   +1 more source

Bayesian Diallel Analysis Reveals Mx1-Dependent and Mx1-Independent Effects on Response to Influenza A Virus in Mice

G3: Genes, Genomes, Genetics, 2018
Influenza A virus (IAV) is a respiratory pathogen that causes substantial morbidity and mortality during both seasonal and pandemic outbreaks. Infection outcomes in unexposed populations are affected by host genetics, but the host genetic architecture is
Paul L. Maurizio, Martin T. Ferris, Gregory R. Keele, Darla R. Miller, Ginger D. Shaw, Alan C. Whitmore, Ande West, Clayton R. Morrison, Kelsey E. Noll, Kenneth S. Plante, Adam S. Cockrell, David W. Threadgill, Fernando Pardo-Manuel de Villena, Ralph S. Baric, Mark T. Heise, William Valdar   +15 more
doaj   +1 more source

Delay and knowledge mediation in human causal reasoning [PDF]

, 2002
Contemporary theories of causal induction have focussed largely on the question of how evidence in the form of covariations between causes and effects is used to compute measures of causal strength.
Buehner, Marc
core  

The effect of efavirenz versus nevirapine-containing regimens on immunologic, virologic and clinical outcomes in a prospective observational study.

, 2012
OBJECTIVE: To compare regimens consisting of either efavirenz or nevirapine and two or more nucleoside reverse transcriptase inhibitors (NRTIs) among HIV-infected, antiretroviral-naive, and AIDS-free individuals with respect to clinical, immunologic, and
de Wolf, Frank, Justice, Amy, Phillips, Andrew, Casabona, Jordi, Sterne, Jonathan A C, del Amo, Julia, Touloumi, Giota, Keuter, M., Tate, Janet, Vourli, Georgia, Cain, Lauren, Costagliola, Dominique, Bansi, Loveleen, Brouwer, A.E., Bucher, Heiner C, Abgrall, Sophie, Sabin, Caroline, Esteve, Anna, Muga, Roberto, Dofferhoff, A.S.M., van Sighem, Ard, Meyer, Laurence, Hernán, Miguel A, Cain, Lauren E, Lodi, Sara, Sterne, Jonathan AC, Seng, Rémonie, Flier, M. van der, HIV CAUSAL, collaboration, Groot, R. de, Koopmans †, P.P., Sterne, Jonathan, Post, Frank, Hiv-Causal, Collaboration, Robins, James M, Hofstede, H.J.M. ter, ?, ?, Elzi, Luigia, Schölvinck, Elisabeth H., Moreno, Santiago, Logan, Roger, Collaboration, H.-C., HIV-CAUSAL Collaboration, Pérez-Hoyos, Santiago, Ven, A.J.A.M. van der, et al.   +45 more
core   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Effects of Causal Determinism on Causal Learning Trajectories. [PDF]

, 2020
Research on causal learning suggests that people are capable of learning nondeterministic causal relations, but might expectcausal relations to be deterministic in certain contexts. In two experiments, we demonstrated that peoples expectations ofcausal determinism are context-sensitive and can influence causal judgments in a sequential learning task ...
Dinh, Phuong (Phoebe), Danks, David
openaire   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source