Results 121 to 130 of about 917,002 (254)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
The causal manipulation and Bayesian estimation of chain event graphs [PDF]
, 2005 Discrete Bayesian Networks (BNs) have been very successful as a framework both for inference and for expressing certain causal hypotheses. In this paper we present a class of graphical models called the chain event graph (CEG) models, that generalises ...
Riccomagno, Eva, Smith, J. Q.
core
It was (not) me: Causal Inference of Agency in goal-directed actions [PDF]
, 2011 Summary: The perception of one's own actions depends on both sensory information and predictions derived from internal forward models [1].
Martin A. Giese* +10 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Review of Economic StudiesAbstract When inferring causal effects from correlational data, a common practice by professional researchers but also lay people is to control for potential confounders. Inappropriate controls produce erroneous causal inferences. I model decision-makers (DMs) who use endogenous observational data to learn actions’ causal effect on ...
openaire +2 more sources
Individual differences in causal learning and decision making [PDF]
, 2005 This is an accepted author manuscript of an article subsequently published by Elsevier. The final published version can be found here: http://dx.doi.org/10.1016/j.actpsy.2005.04.003In judgment and decision making tasks, people tend to neglect the overall
Osman, M, Shanks, David R
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
In this presentation, I provide a brief overview of quasiexperimental methods of estimating causal impacts using Stata: panel data, matching and reweighting, instrumental variables, and regression discontinuity designs, emphasizing practical ...
Austin Nichols
core
Distilling noise characteristics and prior expectations in multisensory causal inference
The perception of the external world relies on integrating information from multiple sensory modalities. To do this effectively, the brain must determine whether sensory signals come from a common source and, if so, combine them to reduce perceptual ...
Shuze Liu +3 more
core +1 more source