Results 101 to 110 of about 917,002 (254)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Physical and Metaphysical Counterfactuals: Evaluating Disjunctive Actions
Journal of Causal Inference, 2017 The structural interpretation of counterfactuals as formulated in Balke and Pearl (1994a,b) [1, 2] excludes disjunctive conditionals, such as “had X$X$ been x1 or x2$x_1~\mbox{or}~x_2$,” as well as disjunctive actions such as do(X=x1 or X=x2)$do(X=x_1 ...
Pearl Judea
doaj +1 more source
Induction and causal inference [PDF]
The general intention of the thesis is to provide an alternative to traditional inductivist and deductivist accounts of reasoning 'concerning matter of fact and existence' which not only more accurately characterises the inferential procedures which we ...
Lowe, E. Jonathan
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Bayesian Inference of Causal Effects for an Ordinal Outcome in Randomized Trials
Journal of Causal Inference, 2018 In randomized trials in which two treatment arms are compared with a binary outcome, the causal effect can be identified by assuming that the two treatment arms are exchangeable.
Chiba Yasutaka
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Confounding Equivalence in Causal Inference
Journal of Causal Inference, 2014 The paper provides a simple test for deciding, from a given causal diagram, whether two sets of variables have the same bias-reducing potential under adjustment.
Pearl Judea, Paz Azaria
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A Conditional Randomization Test to Account for Covariate Imbalance in Randomized Experiments
Journal of Causal Inference, 2016 We consider the conditional randomization test as a way to account for covariate imbalance in randomized experiments. The test accounts for covariate imbalance by comparing the observed test statistic to the null distribution of the test statistic ...
Hennessy Jonathan +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source