Results 101 to 110 of about 451,043 (309)

Kointegrasi dan kausalitas pasar saham Big 5 ASEAN: Tax Amnesty gelombang I

Journal of Business & Banking, 2017
The first batch of Tax Amnesty policy in Indonesia can affect the economy in other countries because of international cooperation, especially in ASEAN. This study tried to see the cointegration and the causality between stock market indices in the Big 5 ...
Loe Irene Kusuma, Noviana Anggun, Gesti Memarista   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

From bites to bytes: understanding how and why individual malaria risk varies using artificial intelligence and causal inference

Frontiers in Genetics
With an estimated 263 million cases recorded worldwide in 2023, malaria remains a major global health challenge, particularly in tropical regions with limited healthcare access.
Adèle Helena Ribeiro, Júlia M. P. Soler, Rodrigo M. Corder, Marcelo U. Ferreira, Marcelo U. Ferreira, Dominik Heider   +5 more
doaj   +1 more source

Dynamic Causality

, 2023
There have been a number of attempts to develop a formal definition of causality that accords with our intuitions about what constitutes a cause. Perhaps the best known is the “modified” definition of actual causality, HPm, due to Halpern. In this paper, we argue that HPm gives counterintuitive results for some simple causal models.
Maksim Gladyshev, Natasha Alechina, Mehdi Dastani, Dragan Doder, Brian Logan 0001   +4 more
openaire   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Maine de Biran : métaphysique et psychologie

Astérion
What can we expect from metaphysics? Defending metaphysics against its enemies and its enemies against themselves (Ideologists), according to Maine de Biran, requires a twofold struggle, capable of avoiding both the dangers of abstract metaphysics that ...
Anne Devarieux
doaj   +1 more source

Exploring the causal association of immunophenotypes on gestational diabetes mellitus based on Mendelian randomization [PDF]

Yixue xinzhi zazhi
Objective To explore the causal relationship between immune cell phenotypes and the risk of developing gestational diabetes mellitus (GDM) by using Mendelian randomization (MR).Methods Using genome-wide association study data from European populations ...
WANG Juan, WANG Qiong, LIN Xingguang, YE Xiaohe, SHEN Li   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Association of ankylosing spondylitis with cardiovascular disease: a bidirectional two-sample mendelian randomization study

Frontiers in Genetics
BackgroundsCurrent observational investigations hint at a potential linkage between ankylosing spondylitis and cardiovascular wellness. However, the nature of this causality remains to be elucidated.
Pengyu Liu, Juju Shang, Zhi Qi, Shenglei Qiu, Xiaolei Lai, Lixiao Shi, Zhenmin Zhang, Mingxuan Li, Linjing Yang   +8 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source