Results 101 to 110 of about 385,289 (314)

From bites to bytes: understanding how and why individual malaria risk varies using artificial intelligence and causal inference

Frontiers in Genetics
With an estimated 263 million cases recorded worldwide in 2023, malaria remains a major global health challenge, particularly in tropical regions with limited healthcare access.
Adèle Helena Ribeiro, Júlia M. P. Soler, Rodrigo M. Corder, Marcelo U. Ferreira, Marcelo U. Ferreira, Dominik Heider   +5 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Nonlinear causality testing with stepwise multivariate filtering [PDF]

This study explores the direction and nature of causal linkages among six currencies denoted relative to United States dollar (USD), namely Euro (EUR), Great Britain Pound (GBP), Japanese Yen (JPY), Swiss Frank (CHF), Australian Dollar (AUD) and Canadian
Stelios Bekiros
core  

Maine de Biran : métaphysique et psychologie

Astérion
What can we expect from metaphysics? Defending metaphysics against its enemies and its enemies against themselves (Ideologists), according to Maine de Biran, requires a twofold struggle, capable of avoiding both the dangers of abstract metaphysics that ...
Anne Devarieux
doaj   +1 more source

Exploring the causal association of immunophenotypes on gestational diabetes mellitus based on Mendelian randomization [PDF]

Yixue xinzhi zazhi
Objective To explore the causal relationship between immune cell phenotypes and the risk of developing gestational diabetes mellitus (GDM) by using Mendelian randomization (MR).Methods Using genome-wide association study data from European populations ...
WANG Juan, WANG Qiong, LIN Xingguang, YE Xiaohe, SHEN Li   +4 more
doaj   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Association of ankylosing spondylitis with cardiovascular disease: a bidirectional two-sample mendelian randomization study

Frontiers in Genetics
BackgroundsCurrent observational investigations hint at a potential linkage between ankylosing spondylitis and cardiovascular wellness. However, the nature of this causality remains to be elucidated.
Pengyu Liu, Juju Shang, Zhi Qi, Shenglei Qiu, Xiaolei Lai, Lixiao Shi, Zhenmin Zhang, Mingxuan Li, Linjing Yang   +8 more
doaj   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Causal Structure Learning with Conditional and Unique Information Groups-Decomposition Inequalities

Entropy
The causal structure of a system imposes constraints on the joint probability distribution of variables that can be generated by the system. Archetypal constraints consist of conditional independencies between variables.
Daniel Chicharro, Julia K. Nguyen
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source