Results 81 to 90 of about 451,043 (309)

Osteoporosis and coronary heart disease: a bi-directional Mendelian randomization study

Frontiers in Endocrinology
BackgroundOsteoporosis (OP) and cardiovascular disease (CVD) are major global public health issues, especially exacerbated by the challenges of an aging population.
Junsheng Zhang, Pai Xu, Rongcan Liu, Jin Min Gyu, Peng Cao, Chan Kang   +5 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Guidelines for investigating causality of sequence variants in human disease

Nature, 2014
The discovery of rare genetic variants is accelerating, and clear guidelines for distinguishing disease-causing sequence variants from the many potentially functional variants present in any human genome are urgently needed. Without rigorous standards we
D. MacArthur, D. MacArthur, T. Manolio, D. Dimmock, H. Rehm, J. Shendure, G. Abecasis, D. Adams, R. Altman, S. Antonarakis, Euan A. Ashley, J. Barrett, L. Biesecker, Donald F. Conrad, G. Cooper, Nancy J. Cox, Mark J. Daly, M. Daly, M. Gerstein, David B. Goldstein, J. Hirschhorn, J. Hirschhorn, S. Leal, L. Pennacchio, L. Pennacchio, J. Stamatoyannopoulos, S. Sunyaev, David Valle, B. Voight, W. Winckler, W. Winckler, C. Gunter   +31 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Causal Set Theory is (Strongly) Causal

Foundations of Physics
Abstract Causal Set Theory (CST) is a promising approach to fundamental physics that seems to treat causation as a basic posit. But in exactly what sense is CST causal? We argue that if the growth dynamics is interpreted as a physical process, then CST employs relations of actual causation between causal set elements, whereby elements bring ...
Baron, Sam, Le Bihan, Baptiste
openaire   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

On the Synergy of Probabilistic Causality Computation and Causality Checking [PDF]

, 2013
In recent work on the safety analysis of systems we have shown how causal relationships amongst events can be algorithmically inferred from probabilistic counterexamples and subsequently be mapped to fault trees. The resulting fault trees were significantly smaller and hence easier to understand than the corresponding probabilistic counterexample, but ...
Leitner-Fischer, Florian, Leue, Stefan
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source