Results 91 to 100 of about 451,043 (309)

Association between hypothyroidism and obstructive sleep apnea: a bidirectional Mendelian randomization study combined with the geo database

open access: yesFrontiers in Neurology
BackgroundThe causal relationship between hypothyroidism and obstructive sleep apnea (OSA) remains controversial. Therefore, our research used a bidirectional Mendelian randomization (MR) method in an attempt to determine the causal relationship between ...
Mingyu Zhao   +6 more
doaj   +1 more source

The causal relationship between Bitcoin attention and Bitcoin returns: Evidence from the Copula-based Granger causality test

open access: yesFinance Research Letters, 2019
This paper examines the causal relationship between Bitcoin attention (measured by the Google Trends search queries) and Bitcoin returns for the period from January 1, 2013, to December 31, 2017.
Shabbir Dastgir   +4 more
semanticscholar   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Gazzâlî’nin Mûcizeye Yaklaşımının Tehâfütü’l-Felâsife Bağlamında Kuantum Kuramı Açısından Değerlendirilmesi

open access: yesKader
Klasik fizik anlayışını değiştiren kuantum kuramı, bilimsel sahada ilk defa ortaya çıkan indeterminizm olması bakımından felsefe ve teoloji alanlarında da büyük etkiler meydana getirmiştir.
Ahmet Çelik, Ayşe Kocabaş
doaj   +1 more source

Regularities and causality; generalizations and causal explanations

open access: yesStudies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 2005
Machamer, Darden, and Craver argue (Mechanism) that causal explanations explain effects by describing the operations of the mechanisms (systems of entities engaging in productive activities) which produce them. One of the aims of this paper is to take advantage of neglected resources of Mechanism to rethink the traditional idea (Regularism) that actual
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Post-traumatic Appendicitis in Pediatric Patients: A Report of Three Cases

open access: yesIatreia
Introduction: Acute appendicitis is the most common surgical emergency in pediatric patients. However, the occurrence of this condition following abdominal trauma is rare, representing only 0.3% of all causes, with few case reports in the medical ...
Alvarez-Carrascal, Juan Manuel   +1 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Causality-driven feature selection and domain adaptation for enhancing chemical foundation models in downstream tasks

open access: yesMachine Learning: Science and Technology
Recent advancements in large foundation models have revealed impressive capabilities in mastering complex chemical language representations. These models undergo a task-agnostic learning phase, characterized by pre-training on extensive unlabeled corpora
Eduardo Soares   +7 more
doaj   +1 more source

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