Results 71 to 80 of about 473,721 (315)

Osteoporosis and coronary heart disease: a bi-directional Mendelian randomization study

Frontiers in Endocrinology
BackgroundOsteoporosis (OP) and cardiovascular disease (CVD) are major global public health issues, especially exacerbated by the challenges of an aging population.
Junsheng Zhang, Pai Xu, Rongcan Liu, Jin Min Gyu, Peng Cao, Chan Kang   +5 more
doaj   +1 more source

Generic versus Single-Case Causality: The Case of Autopsy [PDF]

, 2009
This paper addresses questions about how the levels of causality (generic and single-case causality) are related. One question is epistemological: can relationships at one level be evidence for relationships at the other level?
Russo, Frederica, Russo, Federica, Federica Russo, Jon Williamson, WILLIAMSON J., Williamson, Jon   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Attribution of Terrestrial Near‐Surface Wind Speed Changes Across China at a Centennial Scale

Geophysical Research Letters
Near‐surface wind speed (NSWS) over China shows multiple time‐scale changes at a centennial scale, but the contributions of internal variability (IV), anthropogenic forcing (ANT), and natural forcing (NAT) to those changes remain unknown.
Jinlin Zha, Ting Chuan, Jian Wu, Deming Zhao, Meng Luo, Jinming Feng, Wenxuan Fan, Cheng Shen, Huiping Jiang   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Expectations of Causal Determinism in Causal Learning.

, 2022
Causal learning is shaped by people’s prior beliefs, including their expectations. In this paper, we specifically examine expectations of determinism: do they vary with perceptual features of physical causal events, and how do they influence subsequent causal learning from data?
Dinh, Phuong (Phoebe) Ngoc, Danks, David
openaire   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Decomposing Granger causality over the spectrum. [PDF]

We develop a bivariate spectral Granger-causality test that can be applied at each individual frequency of the spectrum. The spectral approach to Granger causality has the distinct advantage that it allows to disentangle (potentially) different Granger ...
Croux, Christophe, Dekimpe, Marnik, Lemmens, Aurélie   +2 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source