Results 61 to 70 of about 385,289 (314)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
COSMIC EVIDENCE AND NATURAL-SCIENCE THEORIES [PDF]
Hum, 2008 Aspiration for discovering one necessary creature, who establishes visible and changeable cosmos, has existed in the early period of philosophical thinking. In philosophical tradition the most acknowledged way of determining existence of such creature
Mate Buntić
doaj
Unveiling and Causalizing CoT: A Causal Pespective
CoRRAlthough Chain-of-Thought (CoT) has achieved remarkable success in enhancing the reasoning ability of large language models (LLMs), the mechanism of CoT remains a ``black box''. Even if the correct answers can frequently be obtained, existing CoTs struggle to make the reasoning understandable to human.
Jiarun Fu +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Quantile treatment effect estimation with dimension reduction
Statistical Theory and Related Fields, 2020 Quantile treatment effects can be important causal estimands in evaluation of biomedical treatments or interventions for health outcomes such as medical cost and utilisation.
Ying Zhang +3 more
doaj +1 more source
Expectations of Causal Determinism in Causal Learning.
, 2022 Causal learning is shaped by people’s prior beliefs, including their expectations. In this paper, we specifically examine expectations of determinism: do they vary with perceptual features of physical causal events, and how do they influence subsequent causal learning from data?
Dinh, Phuong (Phoebe) Ngoc, Danks, David
openaire +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Attribution of Terrestrial Near‐Surface Wind Speed Changes Across China at a Centennial Scale
Geophysical Research LettersNear‐surface wind speed (NSWS) over China shows multiple time‐scale changes at a centennial scale, but the contributions of internal variability (IV), anthropogenic forcing (ANT), and natural forcing (NAT) to those changes remain unknown.
Jinlin Zha +8 more
doaj +1 more source