Results 51 to 60 of about 385,289 (314)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Short and long run causality measures: theory and inference [PDF]

open access: yes, 2008
The concept of causality introduced by Wiener (1956) and Granger (1969) is defined in terms of predictability one period ahead. This concept can be generalized by considering causality at a given horizon h, and causality up to any given horizon h ...
Taamouti, Abderrahim   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Plasma fatty acids and attention deficit hyperactivity disorder: a Mendelian randomization investigation

open access: yesFrontiers in Psychiatry
BackgroundAttention deficit hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder of childhood, and pathogenesis is not fully understood.
Kangning Zhou   +5 more
doaj   +1 more source

Time Series Analysis of Causal Relationship among Sectoral Labor Productivity in Turkey

open access: yesTurkish Journal of Agriculture: Food Science and Technology, 2017
In this paper, we investigate the causal relationship in terms of labor productivity among GDP and its constituent three main sectors, e.g. agricultural, industrial and services sectors, in Turkey for the period of 1988-2015.
Cevher Özden, Filiz Yetiz
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

A study on large-scale disease causality discovery from biomedical literature

open access: yesBMC Medical Informatics and Decision Making
Background Biomedical semantic relationship extraction could reveal important biomedical entities and the semantic relationships between them, providing a crucial foundation for the biomedical knowledge discovery, clinical decision making and other ...
Shirui Yu   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Causality-based Testing of Autonomous Driving Systems

open access: yes, 2023
 This is the replication package for " Causality-based Testing of Autonomous Driving Systems ". 
CART (14488355)
core   +1 more source

Cathepsins and cancer risk: a Mendelian randomization study

open access: yesFrontiers in Endocrinology
BackgroundPrevious observational epidemiological studies reported an association between cathepsins and cancer, however, a causal relationship is uncertain.
Tingting Deng   +10 more
doaj   +1 more source

Home - About - Disclaimer - Privacy