Results 41 to 50 of about 269,150 (267)
A study on large-scale disease causality discovery from biomedical literature
BMC Medical Informatics and Decision MakingBackground Biomedical semantic relationship extraction could reveal important biomedical entities and the semantic relationships between them, providing a crucial foundation for the biomedical knowledge discovery, clinical decision making and other ...
Shirui Yu +4 more
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Cathepsins and cancer risk: a Mendelian randomization study
Frontiers in EndocrinologyBackgroundPrevious observational epidemiological studies reported an association between cathepsins and cancer, however, a causal relationship is uncertain.
Tingting Deng +10 more
doaj +1 more source
Causal imprinting in causal structure learning [PDF]
Cognitive Psychology, 2012 Suppose one observes a correlation between two events, B and C, and infers that B causes C. Later one discovers that event A explains away the correlation between B and C. Normatively, one should now dismiss or weaken the belief that B causes C. Nonetheless, participants in the current study who observed a positive contingency between B and C followed ...
Eric G, Taylor, Woo-Kyoung, Ahn
openaire +2 more sources
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Stable Causal Relationships Are Better Causal Relationships [PDF]
Cognitive Science, 2018 AbstractWe report three experiments investigating whether people's judgments about causal relationships are sensitive to the robustness orstabilityof such relationships across a range of background circumstances. In Experiment 1, we demonstrate that people are more willing to endorse causal and explanatory claims based on stable (as opposed to unstable)
Vasilyeva, Nadya +2 more
openaire +3 more sources
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
COSMIC EVIDENCE AND NATURAL-SCIENCE THEORIES [PDF]
Hum, 2008 Aspiration for discovering one necessary creature, who establishes visible and changeable cosmos, has existed in the early period of philosophical thinking. In philosophical tradition the most acknowledged way of determining existence of such creature
Mate Buntić
doaj
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
Quantile treatment effect estimation with dimension reduction
Statistical Theory and Related Fields, 2020 Quantile treatment effects can be important causal estimands in evaluation of biomedical treatments or interventions for health outcomes such as medical cost and utilisation.
Ying Zhang +3 more
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FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source