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Caveolae/raft-dependent endocytosis [PDF]

open access: yesJournal of Cell Biology, 2003
Although caveolae are well-characterized subdomains of glycolipid rafts, their distinctive morphology and association with caveolins has led to their internalization being considered different from that of rafts. In this review, we propose that caveolae and rafts are internalized via a common pathway, caveolae/raft-dependent endocytosis, defined by its
Ivan Robert Nabi
exaly   +3 more sources
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Myocardial Tissue Caveolae

Comprehensive Physiology, 2015
ABSTRACTCaveolae and their coat proteins, caveolins (Cav), are cave‐like invaginations found in the plasma membrane of a variety of cells. These unique vesicles and their coat proteins, Cavs, have diverse effects on endothelial function, nitric oxide synthesis regulation, signal transduction, cholesterol metabolism, and apoptosis. Animal studies in Cav
Vani P, Sanon   +3 more
openaire   +2 more sources

Caveolae and signaling

Current Opinion in Lipidology, 2001
Caveolae, cholesterol-rich invaginations of the plasma membrane, have been implicated as scaffolds where signaling complexes are assembled, and as portals to which recycling or newly synthesized free cholesterol is transported prior to efflux or redistribution.
openaire   +2 more sources

Membrane microdomains and caveolae

Current Opinion in Cell Biology, 1999
Glycosphingolipid- and cholesterol-enriched microdomains, or rafts, within the plasma membrane of eukaryotic cells have been implicated in many important cellular processes, such as polarized sorting of apical membrane proteins in epithelial cells and signal transduction.
Kurzchalia, T. V., Parton, RG
openaire   +3 more sources

Life without caveolae

Nature Reviews Molecular Cell Biology, 2001
Many mammalian cells have indentations in the plasma membrane called caveolae, but exactly what these flask-shaped pits do remains unclear. In a Perspective, Parton discusses the characteristics of caveolin-1-deficient mice that lack caveolae ( Drab et al.).
exaly   +5 more sources

Caveolae and Cancer

2009
All blood vessels are lined by a layer of endothelial cells that help to control vascular permeability. The luminal surface of vascular endothelial cells is studded with transport vesicles called caveolae that are directly in contact with the blood and can transport molecules into and across the endothelium. The vasculature within distinct tissue types
Kerri A, Massey, Jan E, Schnitzer
openaire   +2 more sources

Caveolae and caveolins

Current Opinion in Cell Biology, 1996
In the past year, we have witnessed considerable progress towards an understanding of the workings of caveolae. Highlights include the identification of new caveolin family members, the characterization of VIP21-caveolin as a cholesterol-binding oligomeric protein, and evidence for functional interactions between caveolins and heterotrimeric G proteins.
openaire   +3 more sources

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