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Current Opinion in Cell Biology, 1996
In the past year, we have witnessed considerable progress towards an understanding of the workings of caveolae. Highlights include the identification of new caveolin family members, the characterization of VIP21-caveolin as a cholesterol-binding oligomeric protein, and evidence for functional interactions between caveolins and heterotrimeric G proteins.
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In the past year, we have witnessed considerable progress towards an understanding of the workings of caveolae. Highlights include the identification of new caveolin family members, the characterization of VIP21-caveolin as a cholesterol-binding oligomeric protein, and evidence for functional interactions between caveolins and heterotrimeric G proteins.
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Comprehensive Physiology, 2015
ABSTRACT Caveolae and their coat proteins, caveolins (Cav), are cave‐like invaginations found in the plasma membrane of a variety of cells. These unique vesicles and their coat proteins, Cavs, have diverse effects on endothelial function, nitric oxide synthesis regulation, signal transduction, cholesterol ...
Vani P, Sanon +3 more
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ABSTRACT Caveolae and their coat proteins, caveolins (Cav), are cave‐like invaginations found in the plasma membrane of a variety of cells. These unique vesicles and their coat proteins, Cavs, have diverse effects on endothelial function, nitric oxide synthesis regulation, signal transduction, cholesterol ...
Vani P, Sanon +3 more
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Membrane microdomains and caveolae
Current Opinion in Cell Biology, 1999Glycosphingolipid- and cholesterol-enriched microdomains, or rafts, within the plasma membrane of eukaryotic cells have been implicated in many important cellular processes, such as polarized sorting of apical membrane proteins in epithelial cells and signal transduction.
Kurzchalia, T. V., Parton, RG
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Science, 2001
Many mammalian cells have indentations in the plasma membrane called caveolae, but exactly what these flask-shaped pits do remains unclear. In a Perspective, Parton discusses the characteristics of caveolin-1-deficient mice that lack caveolae ( Drab et al.).
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Many mammalian cells have indentations in the plasma membrane called caveolae, but exactly what these flask-shaped pits do remains unclear. In a Perspective, Parton discusses the characteristics of caveolin-1-deficient mice that lack caveolae ( Drab et al.).
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Caveolae and signalling in cancer
Nature Reviews Cancer, 2015It has been over 20 years since the discovery that caveolar lipid rafts function as signalling organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most extensively studied subset of lipid rafts. A newly emerging paradigm is that changes in caveolae also generate tumour metabolic heterogeneity.
Martinez-Outschoorn, Ubaldo E +2 more
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Regulation of eNOS in Caveolae
2012Caveolae are a specialized subset of lipid domains that are prevalent on the plasma membrane of endothelial cells. They compartmentalize signal transduction molecules which regulate multiple endothelial functions including the production of nitric oxide (NO) by the caveolae resident enzyme endothelial NO synthase (eNOS).
Chieko, Mineo, Philip W, Shaul
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Caveolae and the Regulation of Endocytosis
2012Although clathrin-mediated endocytosis constitutes the main pathway for internalization of extracellular ligands and plasma membrane components it has generally been accepted that other uptake mechanisms-caveolae-mediated and noncaveolar raft-dependent endocytosis-also exist.
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2007
Based on work in the last 15 years, caveolae are now recognized as rather complex and dynamic plasma membrane domains with important roles in cellular uptake of molecules, signal transduction, lipid homeostasis, and tumorigenesis. Functionally, caveolae orchestrate very specific events in distinct cell types, thereby making these organelles one of the ...
Stuart A. Ross +2 more
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Based on work in the last 15 years, caveolae are now recognized as rather complex and dynamic plasma membrane domains with important roles in cellular uptake of molecules, signal transduction, lipid homeostasis, and tumorigenesis. Functionally, caveolae orchestrate very specific events in distinct cell types, thereby making these organelles one of the ...
Stuart A. Ross +2 more
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Atherosclerosis, Caveolae and Caveolin-1
2012Atherosclerosis is a disease of the blood vessel characterized by the development of an arterial occlusion containing lipid and cellular deposits. Caveolae are 50-100 nm cell surface plasma membrane invaginations that are believed to play an important role in the regulation of cellular signaling and transport of molecules among others. These organelles
Pavlides, Stephanos +4 more
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Trends in Biochemical Sciences, 2001
Abstract The European Research Conference (EURESCO) on Microdomains, lipid rafts and caveolae was held on 19–24 May 2001 in San Feliu de Guixols, Spain.
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Abstract The European Research Conference (EURESCO) on Microdomains, lipid rafts and caveolae was held on 19–24 May 2001 in San Feliu de Guixols, Spain.
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