Results 141 to 150 of about 29,154 (226)
Advanced Science, Volume 13, Issue 50, 7 September 2026.We introduced genetically encodable, receptor‐independent nanobody‐CPP chimeras, termed endobodies, as robust and modular membrane protein degraders. Additionally, proteasome‐targeting domain (PTD)‐tethered endobody demonstrates further enhanced degradation potency.
Chengjian Zhou +3 more
wiley +1 more source
Hemoglobin's α‐Helix‐to‐β‐Sheet Transition Enables Targeted mRNA Delivery to the Lung
Advanced Science, Volume 13, Issue 50, 7 September 2026.Acidic heating converts hemoglobin into β‐sheet‐rich fibrils with positively charged surfaces. These hemoglobin fibrils electrostatically complex IL‐11 scFv mRNA, selectively bind circulating platelets, and hitchhike to the lung, where they are enriched in fibroblasts.
Xihua Liu +11 more
wiley +1 more source
Cardiovascular disease is the leading cause of death in the USA and is known to be exacerbated by elevated mechanical stress from hypertension. Caveolae are plasma membrane structures that buffer mechanical stress but have been found to be reduced in ...
core
, 2006 The primary function of adipose tissue is to store energy in the form of triacylglycerol, which is hydrolyzed to fatty acids to supply other tissues with energy.
Vener, Alexander, +3 more
core
Advanced Science, Volume 13, Issue 50, 7 September 2026.This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 53, 24 September 2026.Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia +9 more
wiley +1 more source
Aggregate, Volume 7, Issue 9, September 2026.A robust NIR‐II AIE small molecule with multimodal phototheranostic features was rationally constructed through a dual‐acceptor engineering strategy, which enables exceptional NIR‐II fluorescence–photoacoustic–photothermal trimodal imaging and synergistic photodynamic–photothermal therapy in a mouse orthotopic breast cancer model under 808 nm laser ...
Miaomiao Kang +7 more
wiley +1 more source
Drug Delivery With Metal–Organic Frameworks
Angewandte Chemie Novit, Volume 2, Issue 3, September 2026.Metal–organic frameworks (MOFs) have recently entered human clinical trials for cancer radiotherapy, highlighting both the maturity and potential of MOFs as platforms for drug delivery. This minireview introduces the principles of MOF‐based drug delivery and discusses key opportunities and design challenges that will shape the next generation of these ...
Nathalie W. Tarabay +6 more
wiley +1 more source
Membrane Curvature Generation by the Caveolin 8S Complex and the Role of Cholesterol. [PDF]
J Chem Theory ComputVasquez Rodriguez SY, Lazaridis T.
europepmc +1 more source
BMEMat, Volume 4, Issue 3, September 2026.A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie +12 more
wiley +1 more source