Results 111 to 120 of about 55,130 (252)

Signal transduction in neurons: effects of cellular prion protein on fyn kinase and ERK1/2 kinase

Immunity & Ageing, 2010
Background It has been reported that cellular prion protein (PrPc) co-localizes with caveolin-1 and participates to signal transduction events by recruiting Fyn kinase.
Tomasi Vittorio
doaj   +1 more source

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF [PDF]

, 2013
Several pathological processes, such as sepsis and inflammatory bowel disease (IBD), are associated with impairment of intestinal epithelial barrier. Here, we investigated the role of matrix metalloproteinase MMP13 in these diseases.
Albanese CT, An Staes, Carlos López‐Otin, Claude Libert, Elien Van Wonterghem, Eline Dejonckheere, Filip Van Hauwermeiren, Kitagawa H, Kris Gevaert, Lesuffleur T, Nusrat A, Riet De Rycke, Roosmarijn E. Vandenbroucke, Schmitz H, Smirnova MG, Sofie Lodens   +15 more
core   +3 more sources

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Caveolin-1 knockout mice exhibit airway hyperreactivity

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2012
Caveolae are flask-shaped plasma membrane invaginations expressing the scaffolding caveolin proteins. Although caveolins have been found in endothelium and epithelium (where they regulate nitric oxide synthase activity), their role in smooth muscle is still under investigation.
Bharathi, Aravamudan, Sarah K, VanOosten, Lucas W, Meuchel, Pawan, Vohra, Michael, Thompson, Gary C, Sieck, Y S, Prakash, Christina M, Pabelick   +7 more
openaire   +3 more sources

The Role and Therapeutic Potential of Voltage‐Gated Potassium Channel Kv1.3 in Metabolism‐Related Disorders

iNew Medicine, EarlyView.
ABSTRACT Over the past three decades, the global burden of common metabolic diseases such as obesity, diabetes, and atherosclerosis has steadily increased, becoming a serious public health issue that poses a major threat to human health worldwide. Potassium channels, particularly the voltage‐gated Kv1.3 subtype, serve as critical regulators of cellular
Wenjun Zhen, Junda Liu, Xixi Chen, Shi Chen, Yuanyuan Tian, Baoming Wu, Fengxia Yan   +6 more
wiley   +1 more source

Potential of caveolae in the therapy of cardiovascular and neurological diseases. [PDF]

, 2015
Caveolae are membrane micro-domains enriched in cholesterol, sphingolipids and caveolins, which are transmembrane proteins with a hairpin-like structure.
Borroto Escuela, Dasiel Oscar, Franco Fernández, Rafael, Fuxe, Kjell, Navarro Brugal, Gemma   +3 more
core   +2 more sources

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Caveolin-1 sensitizes rat pituitary adenoma GH3 cells to bromocriptine induced apoptosis

Cancer Cell International, 2007
Background Prolactinoma is the most frequent pituitary tumor in humans. The dopamine D2 receptor agonist bromocriptine has been widely used clinically to treat human breast tumor and prolactinoma through inhibition of hyperprolactinemia and induction of ...
Huang Mu-Chiou, Tang Yueh-Bih, Tseng Ting-Yu, Ke Meng-Wei, Li Yi-Hung, Jiang Yan-Nian, Cheng Winston, Ju Yu-Ten   +7 more
doaj   +1 more source

Topographie von Caveolae und Caveolin-1, -2 und -3 im Herz- und Skelettmuskel von Ratten

, 2007
Die Topographie von Caveolae und Caveolin -1,-2 und -3 wurde anhand der Natrium Dodecyl Sulfat-Gefrierbruch-Immunzytochemie im Herz – und Skelettmuskel von Ratten untersucht. Caveolin -1, -2 und -3 stellen das Hauptprotein der Caveolae dar.
Weichel, P. (Peter)
core  

With Regard to the Expression Status of Sarcolemmal Aquaporin 4 in Human Muscular Dystrophies

Neurology and Clinical Neuroscience, EarlyView.
ABSTRACT Human muscular dystrophies are inherited muscle‐wasting diseases caused by the various kinds of gene mutations. Among them, Duchenne muscular dystrophy (DMD) is a representative type. Before the discovery of the causative dystrophin gene of DMD, the fragile myofiber plasma membrane was thought to be the trigger of myofiber necrosis in DMD ...
Yoshihiro Wakayama, Takahiro Jimi
wiley   +1 more source