Results 101 to 110 of about 33,357 (216)
Human placental exposure to pollutant nanoparticles: uptake, translocation and functional impact
The Journal of Physiology, EarlyView.Abstract figure legend Prenatal exposure to pollutant nanoparticles has been increasingly investigated due to concerns about their potential effects on placental function and pregnancy outcomes. Maternal inhalation of pollutant nanoparticles can result in a pro‐inflammatory response; particles can also translocate across the alveolus epithelial barrier
Katherine L. Bethell +3 more
wiley +1 more source
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
Vascular smooth muscle cell mechanotransduction: Pathways, phenotypes and emerging technologies
The Journal of Physiology, EarlyView.Abstract figure legend Vascular smooth muscle cells are exposed to mechanical stimuli from the blood flow and the extracellular matrix. The cells sense the signals from cyclic stretch, shear stress, hydrostatic pressure and matrix stiffness through specialized mechanosensors, such as mechanosensitive ion channels or cell surface receptors including ...
Nivethitha Kota Lakshminaraasimulu +3 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier +3 more
wiley +1 more source
hERG1 channels and potential therapeutics for long QT syndrome
The Journal of Physiology, EarlyView.Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider +3 more
wiley +1 more source
Linchuang shenzangbing zazhi, 2017 Objective Excessive vasoconstriction of interlobar renal artery（ IRA） is one of preliminary manifestations of renal damage in hypertension,during which caveolin-1 plays an important role.
XIE Xiao-ping +5 more
doaj
Nanoparticle‐Mediated Therapy for Glioma: Advances and Prospects
MedComm – Oncology, Volume 5, Issue 3, September 2026.Various nanocarriers, including liposomes, dendrimers, exosomes and gold nanoparticles, are designed to penetrate the blood‐brain barrier and deliver chemotherapy, radiotherapy, immunotherapy, gene therapy, phototherapy, magnetic hyperthermia and sonodynamic therapy for glioma.
Wenqian Jiang +5 more
wiley +1 more source
Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling
Andrology, Volume 14, Issue 6, Page 1831-1846, September 2026.ABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Sen Fu +7 more
wiley +1 more source
TRPA1 Regulates Fibrosis‐Associated Transcriptional Pathways in Human Lung Epithelial Cells
Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.ABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Leevi Halonen +5 more
wiley +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source