Results 81 to 90 of about 29,727,572 (264)

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, EarlyView.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Caveolin-1 in Melanoma Progression [PDF]

, 2011
Cancer is a leading cause of death world wide and mortality due to this group of diseases has doubled in the last 20 years. With an estimated 3 million cases, skin cancer is currently the third most common human malignancy and global incidence is rising at an alarming rate due to environmental changes.
Lorena Lobos-Gonzalez, Lorena Aguilar, Gonzalo Fernandez, Carlos Sanhueza, Andrew F.G   +4 more
openaire   +1 more source

Caveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions

, 2011
In the present study, we aim to elucidate the role of caveolin-1 in modulating astroglial differentiation of neural progenitor cells (NPCs) and the potential mechanisms involved.
Tong, Y, Kwok-Fai So, Yao Tong, Li, Y, Shen, J, Jiangang Shen, So, KF, Yue Li, Wui-Man Lau, Lau, WM   +9 more
core   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1

Biomolecules, 2019
Stress-induced premature cellular senescence is a significant factor in the onset of age-dependent disease in the cardiovascular system. Plasminogen activator inhibitor-1 (PAI-1), a major TGF-β1/p53 target gene and negative regulator of the plasmin ...
Rohan Samarakoon, Stephen P. Higgins, Craig E. Higgins, Paul J. Higgins   +3 more
doaj   +1 more source

Co-regulation of cell polarization and migration by caveolar proteins PTRF/Cavin-1 and caveolin-1. [PDF]

PLoS ONE, 2012
Caveolin-1 and caveolae are differentially polarized in migrating cells in various models, and caveolin-1 expression has been shown to quantitatively modulate cell migration.
Michelle M Hill, Noor Huda Daud, Cho Sanda Aung, Dorothy Loo, Sally Martin, Samantha Murphy, Debra M Black, Rachael Barry, Fiona Simpson, Libin Liu, Paul F Pilch, John F Hancock, Marie-Odile Parat, Robert G Parton   +13 more
doaj   +1 more source

Androgen receptor and caveolin‐1 in prostate cancer [PDF]

IUBMB Life, 2009
AbstractThe androgen receptor (AR) is involved in the development and maintenance of the normal prostate and the development and progression of prostate cancer (PCa). Caveolin‐1 (cav‐1) is an AR co‐regulator. The expression of this integral membrane protein is upregulated in PCa and correlates positively with its development. This review focuses on the
Bennett, Nigel, Hooper, John D., Lee, Cheok Soon (R13259), Gobe, Glenda C.   +3 more
openaire   +5 more sources

Caveolin-1 single-nucleotide polymorphism and arterial stiffness in non-dialysis chronic kidney disease

, 2016
BACKGROUND: Arteriosclerosis is an independent predictor of increased cardiovascular mortality in chronic kidney disease (CKD). Histologically it is characterized by hypertrophy and fibrosis of the arterial media wall leading to increased arterial ...
C.J. Ferro (17225302), Matthew Simmonds (17167288), R. Borrows (17196991), C.E. Duff (17225299), R.P. Steeds (17225314), C.D. Chue (17225296), M. Jesky (17225308), S Chand (6960248), J.N. Townend (17225305), P. Cockwell (7648460), L. Harper (13233267), N.C. Edwards (17225311), S. Stringer (17225317)   +12 more
core   +4 more sources

A nanoplatform that induces dual‐amino acid deprivation to reverse tumor immunosuppression and enhance metabolic immunotherapy

BMEMat, EarlyView.
ZIF‐8‐based nanoparticles co‐delivering CB‐839 (glutaminase inhibitor) and 1‐MT (IDO1 inhibitor), dual‐targeting glutamine/tryptophan metabolism to induce immunogenic cell death, activate STING, block kynurenine production, reverse immunosuppression, and enhance cancer immunotherapy to suppress primary/distant tumors.
Wenli Ning, Yunhan Sun, Mingyang Li, Shilu Liu, Fangjie Yi, Hongfei Wang, Ruibing Bai, Dongdong Liu, Fen Zhao, Guiqiang Zhang, Xiao Fu   +10 more
wiley   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source