Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy
Advanced Science, EarlyView.This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo +7 more
wiley +1 more source
The Role of Caveolin-1 in Intervertebral Disc Degeneration and Regeneration
Global Spine Journal, 2016 Introduction During intervertebral disc (IVD) degeneration, the main cell type in the nucleus pulposus (NP) shifts from notochordal cells (NCs) to chondrocyte-like cells (CLCs).
Frances Bach +9 more
doaj +1 more source
Identification and characterisation of a novel integral membrane protein, shrew-1 that complexes with adherens junctions in polarised cells [PDF]
, 2005 In an attempt to search for potential candidate molecules involved in the pathogenesis of endometriosis, a novel 2910 bp cDNA encoding a putative 411 amino acid protein, shrew-1 was discovered. By computational analysis it was predicted to be an integral
Bharti, Sanita
core
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: The potential role of caveolin-1 in modulating angiogenesis in microgravity environment is unexplored. Methods: Using simulated microgravity by clinostat, we measured the expressions and interactions of caveolin-1 and eNOS in human ...
Fei Shi +9 more
doaj +1 more source
High Caveolin-1 Expression in Tumor Stroma Is Associated with a Favourable Outcome in Prostate Cancer Patients Managed by Watchful Waiting. [PDF]
PLoS ONE, 2016 In the present study we have investigated whether Caveolin-1 expression in non-malignant and malignant prostate tissue is a potential prognostic marker for outcome in prostate cancer patients managed by watchful waiting.
Peter Hammarsten +8 more
doaj +1 more source
A New Role for Caveolin-1 [PDF]
Hypertension, 2009 Caveolae was initially described as plasmalemmal vesicles in the endothelium of the heart in the early 1950s. Since then, caveolae have been identified as the 50- to 100-nm flask-shaped invaginations of the plasma membrane in a wide variety of tissues and cell types.
Yan-Hua Du, Alex F. Chen
openaire +1 more source
Upregulation of Caveolin-1 Correlate with Akt Expression and Poor Prognosis in NPC Patients
, 2017 Objectives: The aim of this study is to investigate the role of Caveolin-1 (Cav-1) in nasopharyngeal carcinoma (NPC) progression and correlated with clinical outcomes.
Wang, Ying-Piao;Lin, Chih-Feng;Tsai, Shu-Chun;Tsai, Ching-Hwa;Yeh, Te-Huei +1 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan +10 more
wiley +1 more source
`Eschericha coli' K1 interactions with human brain microvascular endothelial cells, a primary step in the development of neonatal meningitis [PDF]
Escherichia coli (E. coli) Kl is one of the commonest Gram negative bacteria causing neonatal bacterial meningitis in both developed and developing countries. Haematogenous spread is a key step in E.
Loh, Lip Nam
core +1 more source