Results 51 to 60 of about 33,357 (216)
Advanced Science, EarlyView.Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib +8 more
wiley +1 more source
The Role of Caveolin-1 in Intervertebral Disc Degeneration and Regeneration
Global Spine Journal, 2016 Introduction During intervertebral disc (IVD) degeneration, the main cell type in the nucleus pulposus (NP) shifts from notochordal cells (NCs) to chondrocyte-like cells (CLCs).
Frances Bach +9 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2016 Background/Aims: The potential role of caveolin-1 in modulating angiogenesis in microgravity environment is unexplored. Methods: Using simulated microgravity by clinostat, we measured the expressions and interactions of caveolin-1 and eNOS in human ...
Fei Shi +9 more
doaj +1 more source
The role of caveolin-1 in lipid droplets and their biogenesis [PDF]
Chemistry and Physics of Lipids, 2018 We address unresolved questions of the energetics and mechanism of lipid droplet (LD) biogenesis, and of the role of caveolins in the endoplasmic reticulum (ER) and in mature LDs. LDs are eukaryotic repositories of neutral lipids, which are believed to be synthesised in the ER.
Pezeshkian, Weria +2 more
openaire +3 more sources
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
A New Role for Caveolin-1 [PDF]
Hypertension, 2009 Caveolae was initially described as plasmalemmal vesicles in the endothelium of the heart in the early 1950s. Since then, caveolae have been identified as the 50- to 100-nm flask-shaped invaginations of the plasma membrane in a wide variety of tissues and cell types.
Yan-Hua Du, Alex F. Chen
openaire +1 more source
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.SuperResNET is a powerful integrated software that reconstructs network architecture and molecular distribution of subcellular structures from single molecule localization microscopy datasets. SuperResNET segments the nuclear pore complex and corners, extracts size, shape, and network features of all segmented nuclear pores and uses modularity analysis
Yahongyang Lydia Li +6 more
wiley +1 more source
Oxidative Stress Response Is Mediated by Overexpression and Spatiotemporal Regulation of Caveolin-1
Antioxidants, 2020 Oxidative stress (OS) has been linked to the aetiology of many diseases including osteoarthritis (OA). Recent studies have shown that caveolin-1—a structural protein of plasma membrane’s caveolae—is upregulated in response to OS.
Andreas Goutas +5 more
doaj +1 more source
Experimental and Molecular Medicine, 2023 Despite advances in cancer therapy, the clinical outcome of patients with gastric cancer remains poor, largely due to tumor heterogeneity. Thus, finding a hidden vulnerability of clinically refractory subtypes of gastric cancer is crucial.
Nahee Hwang +11 more
doaj +1 more source
SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells
Animal Models and Experimental Medicine, EarlyView.The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang +6 more
wiley +1 more source