Results 141 to 150 of about 41,045 (251)

Nanoparticle‐Mediated Therapy for Glioma: Advances and Prospects

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Various nanocarriers, including liposomes, dendrimers, exosomes and gold nanoparticles, are designed to penetrate the blood‐brain barrier and deliver chemotherapy, radiotherapy, immunotherapy, gene therapy, phototherapy, magnetic hyperthermia and sonodynamic therapy for glioma.
Wenqian Jiang, Jing Fei, Rangrang Fan, Haifeng Chen, Liangxue Zhou, Gang Guo   +5 more
wiley   +1 more source

An overview of caveolins and their distributions in the endocrine system [PDF]

, 2005
Caveolins, the proteins which were found in "little caves" named caveolae more than 50 years ago, have been revealed to work to maintain the form and functions of many kinds of cells.
Hatanaka, Michiyo, Maeda, Tamaki
core   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source

The Secret (Mitotic) Life of Clathrin

Traffic, Volume 27, Issue 3, September 2026.
A perspective on the function of clathrin at the mitotic spindle during cell division. ABSTRACT The discovery of clathrin was a foundational event in membrane traffic research. Its identification as the major protein component of the coat that surrounds endocytic vesicles kickstarted the biochemical and molecular characterization of endocytosis. During
Stephen J. Royle
wiley   +1 more source

SDCBP Cooperates With YBX1 to Promote ESCC Metastasis by Forming a Positive Feedback Loop With Wnt‐β‐Catenin Signaling Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
SDCBP interacted and cooperated with YBX1 to activate the Wnt/β‐catenin signaling pathway. Then, the activated Wnt/β‐catenin pathway targeted and induced the expression of SDCBP and other oncoproteins. The positive feedback loop between SDCBP and the Wnt/β‐catenin pathway accelerated the ESCC EMT process and promoted tumor metastasis. ABSTRACT Syndecan
Ruijuan Du, Bo Bian, Manyu Luo, Chen Yuan, Kelei Guo, Kai Li, Hui Zhang, Guangji Zhang, Li Han   +8 more
wiley   +1 more source

Non‐Contact Transspatial Regulatory Function of the Extracellular Matrix

Smart Medicine, Volume 5, Issue 4, August 2026.
Non‐contact transspatial regulation of the extracellular matrix (ECM), whereby the ECM remotely modulates cellular behavior without direct physical contact, is proposed and systematically investigated for the first time. This process involves multiple pathways and components, with actin‐dependent macropinocytosis playing a predominant role potentially.
Ting Cao, Chen Yang, Zhengyang Wang, Changmin Shao, Ziye Xu, Baode Chen, Jiayu Zhang, Yongcheng Wang, Fangfu Ye   +8 more
wiley   +1 more source

Engineered Bacterial Membranes as Next‐Generation Platforms for Cancer Immunotherapy

Small Science, Volume 6, Issue 8, August 2026.
Engineered bacterial membrane platforms, including outer membrane vesicles, bacterial ghosts, genetically engineered membranes, and hybrid bacterial–tumor membranes, integrate tumor antigen presentation with intrinsic immune stimulation. These platforms promote dendritic‐cell activation, T‐cell priming, pyroptosis, and synergistic responses with ...
Hafiza Aasia Malik, Urooj Yousaf Virk, Mohamed Salah Attia, Jenny Wilson, Ming Wei   +4 more
wiley   +1 more source

Emerging experimental and bioinformatic approaches in RNA interference‐based pest control research

Insect Molecular Biology, Volume 35, Issue 4, Page 364-375, August 2026.
Double‐stranded RNA (dsRNA) visualization, RNA‐induced silencing complex (RISC)‐bound sRNA‐seq and RNA degradomics allow investigating dsRNA uptake and processing, guide small interfering RNA selection and RISC‐mediated target mRNA cleavages. Transcriptomic and proteomic profiles of genome‐wide responses to dsRNA, including off‐target and compensatory ...
Doga Cedden
wiley   +1 more source

The Functional Study of Caveolin-1 in Rat Pituitary Tumor Cell Line [PDF]

, 2007
泌乳素瘤（prolactinoma）為一常見的腦垂體腺瘤，主要症狀為腦垂體分泌過量泌乳素（prolactin，PRL）。在治療上常使用的藥物為bromocriptine，一種多巴胺D2接受體（dopamine D2 receptor）的促進劑，在研究報告中指出bromocriptine可以引起大鼠腦垂腺瘤細胞株（GH3）的計畫性凋亡，但其機制尚未明瞭。 泌乳素可以調控乳腺發育，而乳腺是哺乳動物一生中少數能經歷數次細胞增殖及退化的組織，若其發育的調控機制不正常，會導致上皮細胞增生及癌化。以雜合扣除法 ...
Li, Yi-Hung, 李一泓
core  

Exosome‐Mediated Delivery of PROTACs for Targeted Protein Degradation in Cancer, Neurodegenerative, Infectious, and Inflammatory Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are heterobifunctional molecules that hijack the ubiquitin‐proteasome system to drive catalytic, sub‐stoichiometric degradation of disease‐associated proteins, offering a mechanistic advantage over occupancy‐driven inhibitors and access to ‘undruggable’ targets.
Sruti Bagchi Ghosh, Rumpa Banerjee, Hailah M. Almohaimeed, Amany I. Almars, Tahani Ahmad ALMatrafi, Fayez M. Saleh, Zuhair M. Mohammedsaleh, Kranti Kiran Reddy Ealla, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source