Results 121 to 130 of about 41,045 (251)
Periodontology 2000, EarlyView.Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng +4 more
wiley +1 more source
Ocadaic acid treatment alters the intracellular localization of caveolin-1 and caveolin-2 in HepG2 cells [PDF]
, 2003 In this paper we provide evidences that protein phosphatases could regulate the intracellular localization of caveolin isoforms in a hepatoma cell line (HepG2).
L. Kiss Anna
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Understanding exosomes in diabetic wound healing
Periodontology 2000, EarlyView.Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad +4 more
wiley +1 more source
Identification of a novel prostate cancer biomarker, caveolin-1: Implications and potential clinical benefit [PDF]
, 2010 Paul G Corn, Timothy C ThompsonDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USAAbstract: While prostate cancer is a common disease in men, it is uncommonly life-threatening.
Timothy C Thompson, Paul G Corn
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Periodontology 2000, EarlyView.Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad +6 more
wiley +1 more source
TMEM16A channel signalling microdomains in the regulation of vascular function
The Journal of Physiology, EarlyView.Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley +1 more source
Frontiers in Dental MedicineAimsCathepsins are essential lysosomal enzymes that maintain organismal homeostasis by degrading extracellular substrates. The inflammatory cytokine interleukin-6 (IL-6) increases the production of cathepsins through the caveolin-1 (Cav-1) and c-Jun N ...
Ayaka Goto +7 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Immunohistochemistry, electrophysiology and pharmacology are useful tools for understanding protein and channel expression and physiological reactions of calcium‐activated chloride channels (CaCCs). Conventional transmission electron microscopy has provided useful 2‐D information on organelle arrangement, localization and ...
Hiromi Tamada
wiley +1 more source
The Molecular Mechanism Depicting Caveolin-1-elicited Regulation of γ-Secretase [PDF]
, 2007 越來越多證據指出，amyloid-precursor protein (APP)的β以及γ的水解可能是發生在細胞膜上一種稱為lipid rafts 的特殊構造中，而caveolin-1 是此種構造上一個重要的結構蛋白。此外，在阿茲海默氏症病患腦部的海馬迴區域，caveolin-1的表現有上升的現象。這些結果都顯示caveolin-1 有可能參與在調節APP 的分解以及阿茲海默氏症的致病過程中。因此，我們嘗試去證明caveolin-1 在γ-secretase主導的蛋白質水解上扮演關鍵的角色。在本實驗中 ...
吳冠勳, Wu, Guan-Hsun
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The Journal of Physiology, EarlyView.Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim +6 more
wiley +1 more source