Results 111 to 120 of about 41,045 (251)
British Journal of Pharmacology, EarlyView.Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher +6 more
wiley +1 more source
Cell Proliferation, EarlyView.AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu +7 more
wiley +1 more source
Genome biology, 2004 The caveolin gene family has three members in vertebrates: caveolin-1, caveolin-2, and caveolin-3. So far, most caveolin-related research has been conducted in mammals, but the proteins have also been found in other animals, including Xenopus laevis, Fugu rubripes, and Caenorhabditis elegans.
Terence M, Williams, Michael P, Lisanti
openaire +1 more source
Cell Proliferation, EarlyView.A zeolitic framework co‐delivers a DNAzyme and a protein prodrug to tumour cells and executes a self‐amplifying therapeutic cascade: the DNAzyme elevates tumour oxidative stress to activate a caged RNase A prodrug. This spatiotemporally controlled synergy converts a genetic input into potent enzymatic cytotoxicity, suppressing tumour growth.
Yan Huang +4 more
wiley +1 more source
Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism : implications for liver regeneration [PDF]
, 2012 Caveolin-1 (CAV1) is a structural protein of caveolae involved in lipid homeostasis and endocytosis. Using newly generated pure Balb/C CAV1 null (Balb/CCAV1−/−) mice, CAV1−/− mice from Jackson Laboratories (JAXCAV1−/−), and CAV1−/− mice developed in the ...
G Leong (13724539) +14 more
core
The siRNA of caveolin-1 suppressed the expression of caveolin-1 in HAFs. [PDF]
, 2014 HAFs were transfected with caveolin-1 siRNA or a non-silencing negative control siRNA using Hiperfect transfection reagent following protocols provided by the manufacturer. After 48 h of incubation the cells were harvested for protein extraction.
Yun Zhang (131894) +3 more
core +1 more source
Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle
The FEBS Journal, EarlyView.EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini +4 more
wiley +1 more source
Up-Regulated Caveolin-1 Accentuates the Metastasis Capability of Lung Adenocarcinoma by Inducing Filopodia Formation [PDF]
, 2007 肺癌在世界多數國家都是癌症死因的前幾名，在台灣也不例外。雖然有許多積極的治療方式及更新更好的化療藥物，肺癌的存活率在過去十年內並沒有太大的改變。其中一個主要的原因就是肺癌常在腫瘤仍然很小時就已經有轉移了，這種現象在肺腺癌細胞更常見，因此，瞭解肺癌轉移的過程，有助於發展新的治療方式。在肺癌的治療方法中，化學療法（化療）佔了很重要的角色。它不僅能延長病患的生命，還能提供更好的生活品質。然而化療常見問題就是癌細胞對化療藥物產生抗藥性。抗藥性的產生可以是癌細胞與生俱來，更常見的是在多次化療療程後產生抗藥性 ...
何肇基, Ho, Chao-Chi
core
Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B [PDF]
, 2015 Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
Jennifer L Brignell +23 more
core +1 more source
MoleculesSome neurodegenerative diseases may be characterized by continuing behavioral and cognitive dysfunction that encompasses memory loss and/or apathy. Alzheimer’s disease is the most typical type of such neurodegenerative diseases that are characterized by ...
Moeka Nakashima +3 more
doaj +1 more source