Results 101 to 110 of about 41,045 (251)
Smart Molecules, EarlyView.The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou +4 more
wiley +1 more source
Caveolin-1 sensitizes vascular smooth muscle cells to mildly oxidized LDL-induced apoptosis [PDF]
, 2008 Oxidized low-density lipoprotein (oxLDL)-induced apoptosis of vascular cells may participate to plaque instability and rupture. Caveolin-1 has emerged as an important regulator of several signal transduction pathways and processes that play a role in ...
Huynh-Do, Uyen +5 more
core +1 more source
Caveolin-1, caveolin-3 and VEGF expression in the masticatory muscles of mdx mice
Folia Histochemica et Cytobiologica, 2011 Duchenne muscular dystrophy (DMD) and murine X-linked muscular dystrophy (mdx), its murine model, are characterized by muscle damage and muscle weakness associated with inflammation and new vessel formation. Caveolins, dystrophin-associated proteins, are involved in the pathogenesis of DMD, because increased numbers of caveolae are found in DMD and mdx
Alexander Spassov +7 more
openaire +4 more sources
Smart Molecules, EarlyView.The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang +8 more
wiley +1 more source
Mechanismen der Caveolin-Genregulation in neuralen Zellsystemen [PDF]
, 2005 Caveolae sind vesikuläre Invaginationen der eukaryontischen Zellmembran, die bei einer Vielzahl zellbiologischer Prozesse eine bedeutende Rolle spielen. Die strukturellen und funktionellen Hauptbestandteile der Caveolae sind die Caveolin-Proteine, welche
Zschocke, Jürgen
core +1 more source
Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling
Andrology, EarlyView.ABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Sen Fu +7 more
wiley +1 more source
Structure-based reassessment of the caveolin signalling model: Do caveolae regulate signaling through caveolin-protein interactions [PDF]
, 2012 Caveolin proteins drive formation of caveolae, specialized cell-surface microdomains that influence cell signaling. Signaling proteins are proposed to use conserved caveolin-binding motifs (CBMs) to associate with caveolae via the caveolin scaffolding ...
Davis, Melissa J. +5 more
core +1 more source
A novel myopathy with autophagic vacuoles associated with biallelic variants in CLN8
Brain Pathology, EarlyView.We describe a novel adult‐onset myopathy with autophagic vacuoles and characteristic features of ceroid lipofuscinosis associated with biallelic CLN8 variants, seizures, and muscle weakness. Autophagosomal/lysosomal deposition of curvilinear, autofluorescent material containing the mitochondrial adenosine triphosphate (ATP) synthase membrane subunit c ...
Ulrika Lindgren +5 more
wiley +1 more source
Caveolin-1 and cholesterol dependent viral entry. [PDF]
, 2013 siRNA and scrambled (sc)RNA were generated and transfected into human corneal cells. A. Real-time RT-PCR for caveolin-1 mRNA confirmed successful reduction of caveolin-1 message (~95%) as compared to scRNA transfected cells (*p=.0002). B.
Santanu Mukherjee (33582) +7 more
core +1 more source
Journal of Extracellular Vesicles, 2014 Background: Tumour-derived extracellular vesicles (EVs) play a role in tumour progression; however, the spectrum of molecular mechanisms regulating EV secretion and cargo selection remain to be fully elucidated.
Kerry L. Inder +11 more
doaj +1 more source