Results 91 to 100 of about 65,797 (247)
Advanced Science, EarlyView.This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma +16 more
wiley +1 more source
The caveolin-1 scaffolding domain peptide decreases phosphatidylglycerol levels and inhibits calcium-induced differentiation in mouse keratinocytes. [PDF]
PLoS ONE, 2013 Phospholipase D2 (PLD2) has been found localized in low-density caveolin-rich membrane microdomains. Our previous study suggested that PLD2 and aquaporin 3 (AQP3) interact in these domains to inhibit keratinocyte proliferation and promote differentiation
Haixia Qin, Wendy B Bollag
doaj +1 more source
Sterol Carrier Protein-2 Directly Interacts with Caveolin-1 in Vitro and in Vivo [PDF]
, 2004 HDL-mediated reverse-cholesterol transport as well as phosphoinositide signaling are mediated through plasma membrane microdomains termed caveolae/lipid rafts.
Atshaves, Barbara P. +7 more
core +2 more sources
Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.SuperResNET is a powerful integrated software that reconstructs network architecture and molecular distribution of subcellular structures from single molecule localization microscopy datasets. SuperResNET segments the nuclear pore complex and corners, extracts size, shape, and network features of all segmented nuclear pores and uses modularity analysis
Yahongyang Lydia Li +6 more
wiley +1 more source
Disparate Entry of Adenoviruses Dictates Differential Innate Immune Responses on the Ocular Surface
Microorganisms, 2019 Human adenovirus infection of the ocular surface is associated with severe keratoconjunctivitis and the formation of subepithelial corneal infiltrates, which may persist and impair vision for months to years following infection.
Matthew R. Pennington +7 more
doaj +1 more source
Caveolae and Lipid Rafts in Endothelium: Valuable Organelles for Multiple Functions
Biomolecules, 2020 Caveolae are flask-shaped invaginations of the plasma membrane found in numerous cell types and are particularly abundant in endothelial cells and adipocytes.
Antonio Filippini, Alessio D’Alessio
doaj +1 more source
Evaluating caveolin interactions: do proteins interact with the caveolin scaffolding domain through a widespread aromatic residue-rich motif? [PDF]
PLoS ONE, 2012 Caveolins are coat proteins of caveolae, small flask-shaped pits of the plasma membranes of most cells. Aside from roles in caveolae formation, caveolins recruit, retain and regulate many caveolae-associated signalling molecules.
Dominic P Byrne +2 more
doaj +1 more source
Allosteric modulation of beta1 integrin function induces lung repair in animal model of emphysema. [PDF]
, 2007 Emphysema is a progressive lung disease characterised by loss of lung parenchyma with associated functional changes including decreased tissue elastance. Here we report beta1 integrin is a novel target for tissue repair and regeneration in emphysema.
Chris J. Armit +6 more
core +1 more source
Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle [PDF]
, 2004 Kawabe, J; Okumura, S; Lee, MC; Sadoshima, J; Ishikawa, Y, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 286(5), H1845-H1852, 2004. "Copyright 2004 by the American Physical Society." publisherMechanical stress contributes to vascular ...
Ishikawa, Y +6 more
core +1 more source
Advanced Intelligent Systems, EarlyView.Hallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Christian Hallgrimson +8 more
wiley +1 more source