Results 71 to 80 of about 65,797 (247)
Advanced Healthcare Materials, EarlyView.Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad +2 more
wiley +1 more source
Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond
Frontiers in Immunology, 2017 Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1 ...
Cecília Jacques Gonçalves de Almeida
doaj +1 more source
Nuclear pore complex-mediated modulation of TCR signaling is required for naïve CD4+ T cell homeostasis. [PDF]
, 2018 Nuclear pore complexes (NPCs) are channels connecting the nucleus with the cytoplasm. We report that loss of the tissue-specific NPC component Nup210 causes a severe deficit of naïve CD4+ T cells.
Borlido, Joana +6 more
core +1 more source
Caveolin-1, caveolae, and glioblastoma [PDF]
Neuro-Oncology, 2012 Glioblastoma multiforme (GBM) is the most common malignant brain tumor and is characterized by high invasiveness, poor prognosis, and limited therapeutic options. Biochemical and morphological experiments have shown the presence of caveolae in glioblastoma cells. Caveolae are flask-shaped plasma membrane subdomains that play trafficking, mechanosensing,
Parat, Marie-Odile, Riggins, Gregory J.
openaire +3 more sources
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Regulation of caveolin and caveolae by cholesterol in MDCK cells
Journal of Lipid Research, 1998 We have examined the expression of caveolin in MDCK cells under conditions that vary cellular cholesterol concentration. Caveolin mRNA levels dropped to one-sixth of control levels after treatment with simvastatin, an inhibitor of cholesterol synthesis ...
Deborah Hailstones +3 more
doaj +1 more source
Interactions between proteins bound to biomembranes
, 2003 We study a physical model for the interaction between general inclusions bound to fluid membranes that possess finite tension, as well as the usual bending rigidity. We are motivated by an interest in proteins bound to cell membranes that apply forces to
A. Albersdorfer +39 more
core +1 more source
Conjugated linoleic acid reduces permeability and fluidity of adipose plasma membranes from obese Zucker rats [PDF]
, 2010 NOTICE: this is the author’s version of a work that was accepted for publication in Biochemical and Biophysical Research Communications. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and ...
Lopes, Paula A. +7 more
core +1 more source
Advanced Science, EarlyView.Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li +9 more
wiley +1 more source
Frontiers in Microbiology, 2018 Peste des petits ruminants virus (PPRV) causes an acute and highly contagious disease of sheep and goats and has spread with alarming speed around the world.
Bo Yang +10 more
doaj +1 more source