Results 61 to 70 of about 57,111 (301)
Molecular Biology of the Cell, 2017 The caveolin scaffolding domain mediates the promigratory activity of Src-phosphorylated (on Y14) caveolin-1 and, specifically, regulation of vinculin tension in focal adhesions.
Fanrui Meng +8 more
semanticscholar +1 more source
, 2011 Caveolin-1, a principle component of caveolae, is present in several cell types known to play an important role in the development of atherosclerosis.
吳造中;王淑慧;管奕奕;曾維功;陳明豐;吳建春;陳玉怜 +1 more
core +1 more source
Caveolin as a Potential Drug Target for Cardiovascular Protection
Frontiers in Physiology, 2012 Caveolae and caveolin are key players in a number of disease processes. Current research indicates that caveolins play a significant role in cardiovascular disease and dysfunction.
Stephanie L Sellers +2 more
doaj +1 more source
SnapShot: Caveolae, Caveolins, and Cavins
Cell, 2013 Caveolae, submicroscopic bulb-shaped plasma membrane pits, are an abundant feature of many mammalian cells (Parton and del Pozo, 2013). Caveolae and the major proteins of caveolae, caveolins (Rothberg et al., 1992), and cavins (Hill et al., 2008), are linked to a number of human diseases such as muscular dystrophy, cardiomyopathy, and lipodys -trophy ...
Ariotti, Nicholas, Parton Robert G.
openaire +5 more sources
Association/Dissociation of Caveolin-1 and Nitric Oxide Synthase in Preserving Renal Medulla Function during Hemorrhage and Aging [PDF]
, 2021 Background: Caveolin-1 is a negative regulator of endothelial nitric oxide synthase (eNOS), as its interaction and binding suppress the activityof eNOS by making caveolin–eNOS complex.
Balaszczuk, Ana María +4 more
core +1 more source
Cells, 2021 Mitochondrial dysfunction plays a pivotal role in the Alzheimer’s Disease (AD) pathology. Disrupted mitochondrial dynamics (i.e., fusion/fission balance), which are essential for normal mitochondria structure and function, are documented in AD.
Shanshan Wang +5 more
doaj +1 more source
Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities.
Journal of Biological Chemistry, 2001 Caveolin-1 is the principal structural protein of caveolae membranes in fibroblasts and endothelia. Recently, we have shown that the human CAV-1 gene is localized to a suspected tumor suppressor locus, and mutations in Cav-1 have been implicated in human
B. Razani +16 more
semanticscholar +1 more source
Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties
Advanced Science, EarlyView.Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez +16 more
wiley +1 more source
, 2011 Caveolin-1 was up-regulated in different drug-resistant cancer cell tines and was suggested to confer drug resistance by different mechanisms. However, the relation of caveolin-1 expression and the clinical response to chemotherapy and prognosis in non ...
何肇基;郭頌鑫;黃佩欣;黃馨儀;楊志新;楊泮池 +1 more
core +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source