Results 61 to 70 of about 41,045 (251)
Lipid compartments and lipid metabolism as therapeutic targets against coronavirus
Frontiers in Immunology, 2023 Lipids perform a series of cellular functions, establishing cell and organelles’ boundaries, organizing signaling platforms, and creating compartments where specific reactions occur.
Daniella Cesar-Silva +5 more
doaj +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Advanced Science, EarlyView.This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai +12 more
wiley +1 more source
Loss of Caveolin-1 Impairs Light Flicker-Induced Neurovascular Coupling at the Optic Nerve Head
Frontiers in Neuroscience, 2021 Glaucoma is a neurodegenerative disease, which results in characteristic visual field defects. Intraocular pressure (IOP) remains the main risk factor for this leading cause of blindness. Recent studies suggest that disturbances in neurovascular coupling
Jing Hong Loo +13 more
doaj +1 more source
Advanced Science, EarlyView.We introduced genetically encodable, receptor‐independent nanobody‐CPP chimeras, termed endobodies, as robust and modular membrane protein degraders. Additionally, proteasome‐targeting domain (PTD)‐tethered endobody demonstrates further enhanced degradation potency.
Chengjian Zhou +3 more
wiley +1 more source
The Interaction of Estrogen Receptor Alpha and Caveolin-3 Regulates Connexin43 Phosphorylation in Metabolic Inhibition-Treated Rat Cardiomyocytes [PDF]
, 2010 Caveolin-3, the major caveolin isoform in cardiomyocytes, plays an important role in the rapid signaling pathways initiated by stimulation of the membrane-associated molecules.
CHUNG, TUN-HUI;WANG, SEU-MEI;LIANG, JYUN-YAN;YANG, SHIH-HUNG;WU, JIAHN-CHUN +1 more
core
Caveolin-1 is required for signaling and membrane targeting of EphB1 receptor tyrosine kinase [PDF]
, 2006 Eph receptor tyrosine kinases are key players during the development of the embryonic vasculature; however, their role and regulation in adult angiogenesis remain to be defined.
Djonov, Valentin +4 more
core +1 more source
Caveolin-1 single-nucleotide polymorphism and arterial stiffness in non-dialysis chronic kidney disease [PDF]
, 2016 BACKGROUND: Arteriosclerosis is an independent predictor of increased cardiovascular mortality in chronic kidney disease (CKD). Histologically it is characterized by hypertrophy and fibrosis of the arterial media wall leading to increased arterial ...
C.J. Ferro (17225302) +12 more
core +2 more sources
Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell
Pharmaceutics, 2020 Nanoparticles (NPs) and submicron particles are increasingly used as carriers for delivering therapeutic compounds to cells. Their entry into the cell represents the initial step in this delivery process, being most of the nanoparticles taken up by ...
Darío Manzanares, Valentín Ceña
doaj +1 more source
Advanced Science, EarlyView.Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib +8 more
wiley +1 more source