Results 1 to 10 of about 24,232,284 (333)
Caveolin-2 associates with intracellular chlamydial inclusions independently of caveolin-1 [PDF]
BMC Infectious Diseases, 2004 Background Lipid raft domains form in plasma membranes of eukaryotic cells by the tight packing of glycosphingolipids and cholesterol. Caveolae are invaginated structures that form in lipid raft domains when the protein caveolin-1 is expressed.
Norkin Leonard C +2 more
doaj +9 more sources
Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. [PDF]
PLoS ONE, 2014 Caveolin-1 is a scaffolding/regulatory protein that interacts with diverse signaling molecules. Caveolin-1(null) mice have marked metabolic abnormalities, yet the underlying molecular mechanisms are incompletely understood.
Takashi Shiroto +7 more
doaj +17 more sources
Interaction of caveolin-1 with Ku70 inhibits Bax-mediated apoptosis. [PDF]
PLoS ONE, 2012 Caveolin-1, the structural protein component of caveolae, acts as a scaffolding protein that functionally regulates signaling molecules. We show that knockdown of caveolin-1 protein expression enhances chemotherapeutic drug-induced apoptosis and inhibits
Huafei Zou +2 more
doaj +8 more sources
Scientific Reports, 2017 Caveolae are abundant flask-shaped invaginations of plasma membranes that buffer membrane tension through their deformation. Few quantitative studies on the deformation of caveolae have been reported.
Masashi Tachikawa +6 more
doaj +2 more sources
Caveolin‐1 deficiency induces premature senescence with mitochondrial dysfunction [PDF]
Aging Cell, 2017 Paradoxical observations have been made regarding the role of caveolin‐1 (Cav‐1) during cellular senescence. For example, caveolin‐1 deficiency prevents reactive oxygen species‐induced cellular senescence despite mitochondrial dysfunction, which leads to
Dong-Min Yu +13 more
semanticscholar +2 more sources
The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1
Biomolecules, 2019 Stress-induced premature cellular senescence is a significant factor in the onset of age-dependent disease in the cardiovascular system. Plasminogen activator inhibitor-1 (PAI-1), a major TGF-β1/p53 target gene and negative regulator of the plasmin ...
Rohan Samarakoon +3 more
doaj +2 more sources
Revolutionizing Autoimmune Research: The Role of Caveolin‐1 [PDF]
Immunity, Inflammation and DiseaseIntroduction Caveolins (Cav) include Cav‐1, Cav‐2, and Cav‐3, with Cav‐1 being the most studied due to its prominent role as a major component of plasma membrane caveolae.
Yanan Gao +8 more
doaj +2 more sources
Nature Communications, 2016 Despite theoretical and physical studies implying that cell-extracellular matrix adhesion geometry governs the orientation of the cell division axis, the molecular mechanisms that translate interphase adhesion geometry to the mitotic spindle orientation ...
Shigeru Matsumura +6 more
semanticscholar +2 more sources
Expression and clinical significance of Caveolin-1 in prostate Cancer after transurethral surgery [PDF]
BMC Urology, 2018 Background Prostate cancer is a common malignancy of the male genitourinary system that occurs worldwide. The current research aims to investigate caveolin-1 expression in prostate cancer tissue and its relationship with pathological grade, clinical ...
Xiaoming Wang, Zhigui Liu, Zhanbin Yang
doaj +2 more sources
SNX19 Interacts with Caveolin-1 and Flotillin-1 to Regulate D1R Endocytosis and Signaling [PDF]
BiomedicinesBackground: Sorting nexin 19 (SNX19) is important in the localization and trafficking of the dopamine D1 receptor (D1R) to lipid raft microdomains. However, the interaction between SNX19 and the lipid raft components caveolin-1 or flotillin-1 and, in ...
Bibhas Amatya +13 more
doaj +2 more sources