Results 101 to 110 of about 24,232,284 (333)
CAVEOLIN-1 in prostate cancer [PDF]
, 2022 High prevalence and mortality of prostate cancer (PCa) is well known global health issue. Ongoing search upon new diagnostic, prognostic and predictive marker is always current. There is need of markers which could identify patients with PCa against benign conditions like prostate hyperplasia (BPH) or inflammation.
Škara, Lucija +5 more
openaire +2 more sources
Phenotypic characterization of human prostatic stromal cells in primary cultures derived from human tissue samples [PDF]
, 2013 Emerging evidence has shown that the tumor microenvironment plays a crucial role in prostate cancer (PCa) development and progression. However, the mechanism(s) through which stromal cells regulate epithelial cells and the differences among prostatic ...
Clemente, Luigi Di +7 more
core +1 more source
Interplay between hepatic mitochondria-associated membranes, lipid metabolism and caveolin-1 in mice
Scientific Reports, 2016 The mitochondria-associated membrane (MAM) is a specialized subdomain of the endoplasmic reticulum (ER) which acts as an intracellular signaling hub. MAM dysfunction has been related to liver disease.
semanticscholar +1 more source
Advanced Science, EarlyView.This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma +10 more
wiley +1 more source
Caveolin-1 interacts with the chaperone complex TCP-1 and modulates its protein folding activity [PDF]
, 2018 .: We report that caveolin-1, one of the major structural protein of caveolae, interacts with TCP-1, a hetero-oligomeric chaperone complex present in all eukaryotic cells that contributes mainly to the folding of actin and tubulin.
Bender, F. +4 more
core
Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond
Frontiers in Immunology, 2017 Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1 ...
Cecília J. G. de Almeida
semanticscholar +1 more source
Caveolin-1 in Cell Migration and Metastasis
Current Molecular Medicine, 2014 Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages, caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms associated with caveolin-1-dependent tumor suppression
Nunez-Wehinger, S. +5 more
openaire +4 more sources
Advanced Science, EarlyView.Owing to the margination effect, rod‐shaped nanoparticles exhibit markedly enhanced co‐localization with endothelial‐adherent platelets (PLTs) under dynamic blood flow. When internalized by PLTs, rod‐shaped PNR@Res inhibit FAK and PI3K/AKT signaling in a morphology‐dependent manner, thereby disrupting their pathological crosstalk with various ...
Bin Zhang +6 more
wiley +1 more source
Oligodendroglial Process Formation is Differentially Affected by Modulating the Intra- and Extracellular Cholesterol Content [PDF]
, 2012 Cholesterol is an essential component of eukaryotic plasma membranes and plays an important role in membrane organization and signaling processes. It is the major lipid component of detergent resistant caveolin-1 containing rafts which previously had ...
Hans H. Althaus +3 more
core +1 more source
Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence
Journal of Biological Chemistry, 2017 Oncogene-induced senescence (OIS) is considered a powerful tumor suppressor mechanism. Caveolin-1 acts as a scaffolding protein to functionally regulate signaling molecules.
D. Volonté +10 more
semanticscholar +1 more source