Results 11 to 20 of about 24,232,284 (333)
Caveolin-1 in renal disease [PDF]
Scientific Journal of Genetics and Gene Therapy, 2018 Renal disease is a major global public health issue that affects 10% of the general population with premature morbidity and mortality related to cardiovascular disease and infection.
S. Chand
semanticscholar +2 more sources
Caveolin‐1, cancer and therapy resistance [PDF]
International Journal of Cancer, 2018 Resistance of solid tumors to chemo‐ and radiotherapy remains a major obstacle in anti‐cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is highly expressed in many tumors and high CAV1 levels were correlated with tumor progression, invasion and metastasis, and thus a worse clinical outcome.
J. Ketteler, D. Klein
semanticscholar +3 more sources
Caveolin-3 and Caveolin-1 Interaction Decreases Channel Dysfunction Due to Caveolin-3 Mutations [PDF]
International Journal of Molecular SciencesCaveolae constitute membrane microdomains where receptors and ion channels functionally interact. Caveolin-3 (cav-3) is the key structural component of muscular caveolae. Mutations in CAV3 lead to caveolinopathies, which result in both muscular dystrophies and cardiac diseases. In cardiomyocytes, cav-1 participates with cav-3 to form caveolae; skeletal
Patrizia Benzoni +15 more
openalex +7 more sources
Fertility & Reproduction, 2023 Background and Aims: Endometrial decidualization is a step in establishing and maintaining pregnancy. Senescence was considered to accompany with decidualization.
Song Zhuo
doaj +1 more source
Nature Materials, 2023 Targeting of tumour vasculature endothelial P-selectin promotes caveolin-1-mediated transcytosis for enhanced blood–brain barrier crossing of therapeutic nanoparticles against medulloblastoma. Medulloblastoma is the most common malignant paediatric brain
Daniel E Tylawsky +12 more
semanticscholar +1 more source
Molecular architecture of the human caveolin-1 complex
bioRxiv, 2022 Membrane sculpting proteins shape the morphology of cell membranes and facilitate remodeling in response to physiological and environmental cues. Complexes of the monotopic membrane protein caveolin function as essential curvature-generating components ...
J. Porta +10 more
semanticscholar +1 more source
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system
Nature Cell Biology, 2022 In response to different types and intensities of mechanical force, cells modulate their physical properties and adapt their plasma membrane (PM). Caveolae are PM nano-invaginations that contribute to mechanoadaptation, buffering tension changes. However,
Fidel-Nicolás Lolo +24 more
semanticscholar +1 more source
Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae
Journal of Cell Biology, 2021 We integrated quantitative nanoscale lipid mapping with molecular dynamic simulations to define the lipid profile within caveolae. Caveolin-1 and cavin1 individually sort distinct plasma membrane lipids.
Yong Zhou +11 more
semanticscholar +1 more source
Caveolin-1-enhanced motility and focal adhesion turnover require tyrosine-14 but not accumulation to the rear in metastatic cancer cells. [PDF]
PLoS ONE, 2012 Caveolin-1 is known to promote cell migration, and increased caveolin-1 expression is associated with tumor progression and metastasis. In fibroblasts, caveolin-1 polarization and phosphorylation of tyrosine-14 are essential to promote migration. However,
Hery Urra +8 more
doaj +1 more source