Results 41 to 50 of about 1,094 (184)

Biogenesis of Caveolae: Stepwise Assembly of Large Caveolin and Cavin Complexes [PDF]

Traffic, 2010
We analyzed the assembly of caveolae in CV1 cells by following the fate of newly synthesized caveolin-1 (CAV1), caveolin-2 and polymerase I and transcript release factor (PTRF)/cavin-1 biochemically and using live-cell imaging. Immediately after synthesis in the endoplasmic reticulum (ER), CAV1 assembled into 8S complexes that concentrated in ER exit ...
Hayer A1, Stoeber M, Bissig C, Helenius A.   +3 more
openaire   +4 more sources

Description of large, well‐preserved Enchodus specimens from the Bearpaw Formation of Alberta, Canada

The Anatomical Record, EarlyView.
Abstract Fishes of the genus Enchodus were abundant and cosmopolitan in the Late Cretaceous, but are primarily known from isolated remains in Canada. Four well‐preserved fish skulls were recovered in recent years from ammolite mines sampling the Bearpaw Formation of Southern Alberta, and are here referred to Enchodus petrosus Cope, 1874.
Luke E. Nelson, Alison M. Murray, Donald B. Brinkman   +2 more
wiley   +1 more source

Caveolae and Lipid Rafts in Endothelium: Valuable Organelles for Multiple Functions

Biomolecules, 2020
Caveolae are flask-shaped invaginations of the plasma membrane found in numerous cell types and are particularly abundant in endothelial cells and adipocytes.
Antonio Filippini, Alessio D’Alessio
doaj   +1 more source

Updated COVID‐19 Vaccines and Health Outcomes in Patients With Autoimmune Rheumatic Conditions

Arthritis &Rheumatology, EarlyView.
Objective We aimed to assess the association between COVID‐19 vaccination status and COVID‐19‐related hospital admissions, need for mechanical ventilation or extracorporeal membrane oxygenation (ECMO), and death in people with autoimmune rheumatic conditions. Methods We conducted a retrospective cohort study using National Clinical Cohort Collaborative
Lesley E. Jackson, A. Jerrod Anzalone, Kenneth G. Saag, Rahima Begum, AKM F. Rahman, Namrata Singh, Kaleb Michaud, Jasvinder A. Singh, Rena C. Patel, Maria I. Danila, on behalf of the National Clinical Cohort Collaborative Consortium, Adam B. Wilcox, Adam M. Lee, Alexis Graves, Alfred (Jerrod) Anzalone, Amin Manna, Amit Saha, Amy Olex, Andrea Zhou, Andrew E. Williams, Andrew M. Southerland, Andrew T. Girvin, Anita Walden, Anjali Sharathkumar, Benjamin Amor, Benjamin Bates, Brian Hendricks, Brijesh Patel, G. Caleb Alexander, Carolyn T. Bramante, Cavin Ward‐Caviness, Charisse Madlock‐Brown, Christine Suver, Christopher G. Chute, Christopher Dillon, Chunlei Wu, Clare Schmitt, Cliff Takemoto, Dan Housman, Davera Gabriel, David A. Eichmann, Diego Mazzotti, Donald E. Brown, Eilis Boudreau, Elaine L. Hill, Emily Carlson Marti, Emily R. Pfaff, Evan French, Farrukh M. Koraishy, Federico Mariona, Fred Prior, George Sokos, Greg Martin, Harold P. Lehmann, Heidi Spratt, Hemalkumar B. Mehta, J. W. Awori Hayanga, Jami Pincavitch, Jaylyn Clark, Jeremy Richard Harper, Jessica Yasmine Islam, Jin Ge, Joel Gagnier, Johanna J. Loomba, John B. Buse, Jomol Mathew, Joni L. Rutter, Julie A. McMurry, Justin Guinney, Justin Starren, Karen Crowley, Katie Rebecca Bradwell, Kellie M. Walters, Ken Wilkins, Kenneth R. Gersing, Kenrick Cato, Kimberly Murray, Kristin Kostka, Lavance Northington, Lee Pyles, Lesley Cottrell, Lili M. Portilla, Mariam Deacy, Mark M. Bissell, Marshall Clark, Mary Emmett, Matvey B. Palchuk, Melissa A. Haendel, Meredith Adams, Meredith Temple‐O'Connor, Michael G. Kurilla, Michele Morris, Nasia Safdar, Nicole Garbarini, Noha Sharafeldin, Ofer Sadan, Patricia A. Francis, Penny Wung Burgoon, Philip R. O. Payne, Randeep Jawa, Rebecca Erwin‐Cohen, Rena C. Patel, Richard A. Moffitt, Richard L. Zhu, Rishikesan Kamaleswaran, Robert Hurley, Robert T. Miller, Saiju Pyarajan, Sam G. Michael, Samuel Bozzette, Sandeep K. Mallipattu, Satyanarayana Vedula, Scott Chapman, Shawn T. O'Neil, Soko Setoguchi, Stephanie S. Hong, Steven G. Johnson, Tellen D. Bennett, Tiffany J. Callahan, Umit Topaloglu, Valery Gordon, Vignesh Subbian, Warren A. Kibbe, Wenndy Hernandez, Will Beasley, Will Cooper, William Hillegass, Xiaohan Tanner Zhang   +127 more
wiley   +1 more source

212 Suppressor of cytokine signalling 3 (socs3) interaction with cavin-1 links socs3 function and cavin-1 stability [PDF]

Heart, 2017
Caveolae are lipid raft microdomains essential for the compartmentalisation and regulation of several signalling pathways e.g. JAK/STAT signalling. Disruption of caveolae is a significant factor in multiple disorders including muscular dystrophy, cardiovascular disease, and cancer.
Jamie Williams, Nasser Alotaiq, Tim Palmer   +2 more
openaire   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Structural Insights into the Organization of the Cavin Membrane Coat Complex

Developmental Cell, 2014
Caveolae are cell-surface membrane invaginations that play critical roles in cellular processes including signaling and membrane homeostasis. The cavin proteins, in cooperation with caveolins, are essential for caveola formation. Here we show that a minimal N-terminal domain of the cavins, termed HR1, is required and sufficient for their homo- and ...
Kovtun, Oleksiy, Tillu, Vikas, Jung, WooRam, Leneva, Natalya, Ariotti, Nicholas, Chaudhary, Natasha, Mandyam, Ramya, Ferguson, Charles, Morgan, Garry, Johnston, Wayne, Harrop, Stephen, Alexandrov, Kirill, Parton, Robert, Collins, Brett   +13 more
openaire   +5 more sources

Prognostic and diagnostic significance of Cavin 2 in lung adenocarcinoma

Archives of Medical Science, 2020
Cavin 2 down-regulation is reported in several malignant tumors and is associated with tumor progression. However, the role of Cavin 2 in lung adenocarcinoma is unknown. This study aimed to investigate the prognostic and diagnostic significance of Cavin 2 in lung adenocarcinoma.Cavin 2 expression levels were examined in 150 cases of lung adenocarcinoma
Wang, Xianguo, Arcani, Diana Maria Cespedes, Zhao, Jingping, Xu, Ming, Zhou, Xuefeng, Yang, Yibin   +5 more
openaire   +2 more sources

Single-molecule analysis reveals self assembly and nanoscale segregation of two distinct cavin subcomplexes on caveolae

eLife, 2014
In mammalian cells three closely related cavin proteins cooperate with the scaffolding protein caveolin to form membrane invaginations known as caveolae.
Yann Gambin, Nicholas Ariotti, Kerrie-Ann McMahon, Michele Bastiani, Emma Sierecki, Oleksiy Kovtun, Mark E Polinkovsky, Astrid Magenau, WooRam Jung, Satomi Okano, Yong Zhou, Natalya Leneva, Sergey Mureev, Wayne Johnston, Katharina Gaus, John F Hancock, Brett M Collins, Kirill Alexandrov, Robert G Parton   +18 more
doaj   +1 more source

Caveolin‐1 enriched apoptotic bodies derived from oral hard palate orchestrate bone remodeling to treat heterotopic ossification

BMEMat, EarlyView.
Downregulated CAV1 in HO is restored via apoptotic bodies from PMSCs, which reprogram bone remodeling by delivering CAV1 to target cells, highlighting the therapeutic role of EV subtypes in heterotopic ossification. Abstract Heterotopic ossification (HO) is a pathological process characterized by ectopic bone formation in non‐osseous tissues, with an ...
Yuchen Wang, Like Tang, Zhou Yu, Wenjin Cai, Qifeng Jiang, Zhikang Wang, Yitong Chen, Kaichen Lai, Ying Wang, Tim Forouzanfar, Chiyuan Ma, Gang Wu, Tingben Huang, Guoli Yang   +13 more
wiley   +1 more source