Results 21 to 30 of about 1,094 (184)

In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish

eLife, 2021
Protein interaction networks are crucial for complex cellular processes. However, the elucidation of protein interactions occurring within highly specialised cells and tissues is challenging.
Zherui Xiong, Harriet P Lo, Kerrie-Ann McMahon, Nick Martel, Alun Jones, Michelle M Hill, Robert G Parton, Thomas E Hall   +7 more
doaj   +1 more source

Human Resources/ Training [PDF]

Visions in Leisure and Business
Essential ingredients in any organization are the individuals who provide programs and services. The important element is that these individuals have the proper perspective in order to provide quality services. The key to success is an effective training
Bryan Cavins
doaj   +2 more sources

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes [PDF]

Journal of Cell Biology, 2009
Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds ...
Bastiani, Michele, Hill, Michelle M., Nixon, Susan J., Lo, Harriet P., Abankwa, Daniel, Luetterforst, Robert, Fernandez-Rojo, Manuel, Breen, Michael R., Vinten, Jorgen, Walser, Piers J., North, Kathryn N., Hancock, John F., Pilch, Paul F., Parton, Robert G., Liu, Libin, Jedrychowski, Mark, Gygi, Steven   +16 more
openaire   +6 more sources

Hypoxia Inhibits Cavin-1 and Cavin-2 Expression and Down-Regulates Caveolae in Adipocytes [PDF]

Endocrinology, 2015
AbstractDuring obesity, a hypoxic state develops within the adipose tissue, resulting in insulin resistance. To understand the underlying mechanism, we analyzed the involvement of caveolae because they play a crucial role in the activation of insulin receptors.
Regazzetti, Claire, Dumas, Karine, Lacas-Gervais, Sandra, Pastor, Faustine, Peraldi, Pascal, Bonnafous, Stéphanie, Dugail, Isabelle, Le Lay, Soazig, Valet, Philippe, Le Marchand-Brustel, Yannick, Tran, Albert, Gual, Philippe, Tanti, Jean-François, Cormont, Mireille, Giorgetti-Peraldi, Sophie   +14 more
openaire   +2 more sources

Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis [PDF]

Nature Communications, 2019
AbstractCaveolae are specialized domains of the plasma membrane. Formation of these invaginations is dependent on the expression of Caveolin-1 or -3 and proteins of the cavin family. In response to stress, caveolae disassemble and cavins are released from caveolae, allowing cavins to potentially interact with intracellular targets.
Kerrie-Ann McMahon, Yeping Wu, Yann Gambin, Emma Sierecki, Vikas A. Tillu, Thomas Hall, Nick Martel, Satomi Okano, Shayli Varasteh Moradi, Jayde E. Ruelcke, Charles Ferguson, Alpha S. Yap, Kirill Alexandrov, Michelle M. Hill, Robert G. Parton   +14 more
openaire   +6 more sources

Lessons from cavin-1 deficiency [PDF]

Biochemical Society Transactions, 2020
Caveolae have been implicated in a wide range of critical physiological functions. In the past decade, the dominant role of cavin-1 in caveolae formation has been established, and it has been recognized as another master regulator for caveolae biology.
openaire   +2 more sources

Energy and Dynamics of Caveolae Trafficking

Frontiers in Cell and Developmental Biology, 2021
Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane domain is characterized and formed by specific lipid binding proteins including ...
Claudia Matthaeus, Justin W. Taraska
doaj   +1 more source

Rosiglitazone drives cavin-2/SDPR expression in adipocytes in a CEBPα-dependent manner. [PDF]

PLoS ONE, 2017
Caveolae are abundant adipocyte surface domains involved in insulin signaling, membrane trafficking and lipid homeostasis. Transcriptional control mechanisms for caveolins and cavins, the building blocks of caveolae, are thus arguably important for ...
Björn Hansson, Catarina Rippe, Dorota Kotowska, Sebastian Wasserstrom, Johanna Säll, Olga Göransson, Karl Swärd, Karin G Stenkula   +7 more
doaj   +1 more source

Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability [PDF]

Nature Communications, 2018
AbstractEffective suppression of JAK–STAT signalling by the inducible inhibitor “suppressor of cytokine signalling 3” (SOCS3) is essential for limiting signalling from cytokine receptors. Here we show that cavin-1, a component of caveolae, is a functionally significant SOCS3-interacting protein.
Williams, Jamie J.L., Al-Otaiq, Nasser, Mullen, William, Burchmore, Richard, Liu, Libin, Baillie, George S., Schaper, Fred, Pilch, Paul F., Palmer, Timothy M.   +8 more
openaire   +6 more sources

Cavin family proteins and the assembly of caveolae

Journal of Cell Science, 2015
ABSTRACT Caveolae are an abundant feature of the plasma membrane in many cells. Until recently, they were generally considered to be membrane invaginations whose formation primarily driven by integral membrane proteins called caveolins. However, the past decade has seen the emergence of the cavin family of peripheral membrane proteins as
Kovtun, Oleksiy, Tillu, Vikas A., Ariotti, Nicholas, Parton, Robert G., Collins, Brett M.   +4 more
openaire   +6 more sources