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CB1 Cannabinoid Receptor Signaling and Biased Signaling [PDF]
Molecules, 2021 The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, pain, and neurodegeneration.
Luciana M. Leo, Mary E. Abood
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Voltage dependence of the cannabinoid CB1 receptor
Frontiers in Pharmacology, 2022 Cannabinoids produce their characteristic effects mainly by binding to two types of G-protein coupled receptors (GPCRs), the CB1 and CB2 cannabinoid receptors.
Esty Goldberger +2 more
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Internalization and Recycling of the CB1 Cannabinoid Receptor [PDF]
Journal of Neurochemistry, 1999 Abstract : Tolerance develops rapidly to cannabis, cannabinoids, and related drugs acting at the CB1 cannabinoid receptor. However, little is known about what happens to the receptor as tolerance is developing. In this study, we have found that CB1 receptors are rapidly internalized following agonist binding and receptor activation ...
K Mackie
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Crystal Structure of the Human Cannabinoid Receptor CB1 [PDF]
Cell, 2016 Cannabinoid receptor 1 (CB1) is the principal target of Δ9-tetrahydrocannabinol (THC), a psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications and a long history of recreational use. CB1 is activated by endocannabinoids and is a promising therapeutic target for pain management, inflammation, obesity, and substance ...
Tian Hua, Kiran Vemuri, Mengchen Pu
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Expression and function of cannabinoid receptors CB1 and CB2 and their cognate cannabinoid ligands in murine embryonic stem cells. [PDF]
PLoS ONE, 2007 Characterization of intrinsic and extrinsic factors regulating the self-renewal/division and differentiation of stem cells is crucial in determining embryonic stem (ES) cell fate.
Shuxian Jiang +8 more
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Canadian Journal of Pain, 2023 Background Preclinical and clinical evidence suggests that cannabis has potential analgesic properties. However, cannabinoid receptor expression and localization within spinal cord pain processing circuits remain to be characterized across sex and ...
Jessica Parnell +8 more
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Frontiers in Cellular Neuroscience, 2021 There is evidence of ghrelinergic-cannabinoidergic interactions in the central nervous system (CNS) that may impact on the plasticity of reward circuits. The aim of this article was to look for molecular and/or functional interactions between cannabinoid
Alejandro Lillo +12 more
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Cannabinoid CB1 receptors regulate salivation
Scientific Reports, 2022 AbstractSaliva serves multiple important functions within the body that we typically take for granted, such as helping prepare food for swallowing and defense against oral pathogens. Dry mouth is a primary symptom of Sjӧgren’s syndrome and is a side effect of many drug treatments.
Kelsey Andreis +6 more
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Signal transduction of the CB1 cannabinoid receptor [PDF]
Journal of Molecular Endocrinology, 2009 The CB1 cannabinoid receptor (CB1R) is the major cannabinoid receptor in neuronal cells and the brain, but it also occurs in endocrine cells and other peripheral tissues. CB1R is a member of the superfamily of G-protein-coupled receptors (GPCRs), which are characterized by seven transmembrane helices.
Gábor, Turu, László, Hunyady
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Cannabinoids facilitate the swallowing reflex elicited by the superior laryngeal nerve stimulation in rats. [PDF]
PLoS ONE, 2012 Cannabinoids have been reported to be involved in affecting various biological functions through binding with cannabinoid receptors type 1 (CB1) and 2 (CB2).
Rahman Md Mostafeezur +5 more
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