Results 11 to 20 of about 22,655 (236)
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. [PDF]
PLoS ONE, 2008 Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation.
Blerina Kola +11 more
doaj +3 more sources
Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]
, 2013 CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Boros, Eszter +7 more
core +1 more source
PLoS ONE, 2011 It is well known that acute challenges with psychostimulants such as amphetamine affect impulsive behavior. We here studied the pharmacology underlying the effects of amphetamine in two rat models of impulsivity, the 5-choice serial reaction time task (5-
Joost Wiskerke +4 more
doaj +1 more source
Optimization of cAMP fluorescence dataset from ACTOne cannabinoid receptor 1 cell line
Data in Brief, 2016 The ACTOne cannabinoid receptor 1 functional system is comprised of transfected HEK cells with the parental cyclic nucleotide gated channel (CNG) co-transfected with cannabinoid receptor 1 (CB1).
Chaela S. Presley +2 more
doaj +1 more source
Frontiers in Pharmacology, 2019 Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly and ...
Daniel García-Rincón +21 more
doaj +1 more source
AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity. [PDF]
PLoS ONE, 2010 The CB1 cannabinoid receptor is the most abundant G-protein coupled receptor in the brain and a key regulator of neuronal excitability. There is strong evidence that CB1 receptor on glutamatergic hippocampal neurons is beneficial to alleviate ...
Stephan Guggenhuber +3 more
doaj +1 more source
AB-MDMSBA-Not a Synthetic Cannabinoid Receptor Agonist. [PDF]
Pharmacol Res PerspectThis study uses classical in vitro pharmacology approaches to establish that AB‐MDMSBA does not bind to or activate the cannabinoid CB1 receptor and therefore should not be classified as a synthetic cannabinoid receptor agonist. ABSTRACT Synthetic cannabinoids remain one of the most prominent classes of New Psychoactive Substances (NPS).
Patel M +4 more
europepmc +2 more sources
The Impact of CB1 Receptor on Inflammation in Skeletal Muscle Cells
Journal of Inflammation Research, 2021 Mansour Haddad Faculty of Pharmacy, Philadelphia University, Amman, JordanCorrespondence: Mansour Haddad Email Dr.man.haddad@gmail.comBackground: Various factors trigger the inflammatory response and cytokine activation in skeletal muscle.
Haddad M
doaj
Cannabinoid receptor type-1: breaking the dogmas [version 1; referees: 3 approved]
F1000Research, 2016 The endocannabinoid system (ECS) is abundantly expressed in the brain. This system regulates a plethora of physiological functions and is composed of cannabinoid receptors, their endogenous ligands (endocannabinoids), and the enzymes involved in the ...
Arnau Busquets Garcia +3 more
doaj +1 more source