Results 181 to 190 of about 1,257,507 (228)

The interaction of Suk-Saiyasna remedy with GABAA and CB1 receptor-targeting drugs: Enhancing hypnotic and sedative effects in in vivo models. [PDF]

J Adv Pharm Technol Res
Damjuti W, Thitikornpong W, Saengow S, Thanusuwannasak T, Fuangfoo T, Boonruab J.   +5 more
europepmc   +1 more source

Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome. [PDF]

Mol Autism
Cosentino L, Urbinati C, Lanzillotta C, De Rasmo D, Valenti D, Pellas M, Quattrini MC, Piscitelli F, Kostrzewa M, Di Domenico F, Pietraforte D, Bisogno T, Signorile A, Vacca RA, De Filippis B.   +14 more
europepmc   +1 more source

Assay of CB1 Receptor Binding

, 2016
Type-1 cannabinoid receptor (CB1), one of the main targets of endocannabinoids, plays a key role in several pathophysiological conditions that affect both central nervous system and peripheral tissues. Today, its biochemical identification and pharmacological characterization, as well as the screening of thousands of novel ligands that might be useful ...
Catani, VM, GASPERI, VALERIA
core   +6 more sources

Some of the next articles are maybe not open access.

Related searches:

The Cannabinoid CB1 Receptor in Schizophrenia

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2021
Converging lines of evidence from epidemiological, preclinical, and experimental studies indicate that the endocannabinoid system may be involved in the pathophysiology of schizophrenia and suggest that the cannabinoid CB1 receptor may be a potential therapeutic target.
Faith Borgan, Michelle Kokkinou, Oliver Howes   +2 more
openaire   +3 more sources

Assay of CB1 Receptor Binding

2022
Type-1 cannabinoid receptor (CB1), one of the main targets of endocannabinoids, plays a key role in several pathophysiological conditions that affect both the central nervous system and peripheral tissues. Today, its biochemical identification and pharmacological characterization, as well as the screening of thousands of novel ligands that might be ...
Gasperi V, Savini I, Catani MV
openaire   +3 more sources

The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-55940)

Behavioural Pharmacology, 2005
It is well established that Cannabis sativa can increase appetite, particularly for sweet and palatable foods. In laboratory animals, cannabinoid CB1 receptor antagonism decreases motivation for palatable foods, and most recently, the CB1 receptor antagonist SR141716A, or rimonabant (Acomplia), was reported to produce weight loss in obese human ...
S J, Ward, L A, Dykstra
openaire   +2 more sources

CB1 Cannabinoid Receptor Ligands

Mini-Reviews in Medicinal Chemistry, 2005
The CB1 receptor is expressed in the central nervous system and numerous other tissues including heart, lung and uterus and has been recognized as an important therapeutic target for pain, appetite modulation, glaucoma, multiple sclerosis and other indications.
Ganesh A, Thakur, Spyros P, Nikas, Alexandros, Makriyannis   +2 more
openaire   +2 more sources

Structural Insights into CB1 Receptor Biased Signaling [PDF]

International Journal of Molecular Sciences, 2019
The endocannabinoid system has emerged as a promising target for the treatment of numerous diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Thus far, two cannabinoid receptors, CB1 and CB2, have been discovered, which are
Rufaida Al Zoubi, Paula Morales, Patricia H Reggio   +2 more
exaly   +3 more sources

Aminopyrazine CB1 receptor inverse agonists

Bioorganic & Medicinal Chemistry Letters, 2008
A series of 5,6-diaryl-2-amino-pyrazines were prepared and found to have antagonist-like properties at the CB1 receptor. Subsequent SAR studies optimized both receptor potency and drug-like properties including solubility and Cytochrome-P450 inhibition potential.
David J, Wustrow, George D, Maynard, Jun, Yuan, He, Zhao, Jianmin, Mao, Qin, Guo, Mark, Kershaw, Jack, Hammer, Robbin M, Brodbeck, Kristen E, Near, Dan, Zhou, David S, Beers, Bertrand L, Chenard, James E, Krause, Alan J, Hutchison   +14 more
openaire   +2 more sources