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Cannabinoid (CB1) Receptor Activation Inhibits Trigeminovascular Neurons
The Journal of Pharmacology and Experimental Therapeutics, 2007Migraine is a common and disabling neurological disorder that involves activation or the perception of activation of the trigeminovascular system. Cannabinoid (CB) receptors are present in brain and have been suggested to be antinociceptive. Here we determined the effect of cannabinoid receptor activation on neurons with trigeminovascular nociceptive ...
Akerman, Simon +2 more
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Multiple mechanisms of CB1 cannabinoid receptors regulation
Brain Research, 2003Agonist-induced regulation of cannabinoid CB1 receptors was examined in HEK-293 cells transfected with CB1 receptors and in neuroblastoma N18TG2 cells that naturally express CB1 receptors. In HEK-293 cells, CB1 receptors internalization proceeded, in parallel, via clathrin-coated pits and caveolae.
Ora, Keren, Yosef, Sarne
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CB1 receptor-mediated respiratory depression by endocannabinoids
Respiratory Physiology & Neurobiology, 2017Endocannabinoids (ECs) are bioactive lipid mediators acting on two distinct cannabinoid receptors (CB1 and CB2), which are ubiquitously expressed in many tissues including the respiratory system. Despite numerous experimental data showing that cannabinomimetics influence respiration, the role of endogenously produced ECs in respiratory control has not ...
Iring, A., Hricisak, L., Benyo, Z.
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Cannabinoid CB1 receptors control conditioned drug seeking
Trends in Pharmacological Sciences, 2005Recent developments have implicated cannabinoid CB1 receptors as a novel target for a new class of therapeutic agents used to treat drug addiction. CB1 receptors are expressed in the motivational circuitry of the brain and modulate drug seeking. Blockade of the CB1 receptor is particularly effective in reducing cue-induced reinstatement of drug seeking,
De Vries, Taco J +1 more
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Non-CB1, Non-CB2 Receptors for Endocannabinoids
2005V Di Marzo, L De Petrocellis
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