Results 31 to 40 of about 19,856 (171)

The Neuroprotective Effects of mGlu1 Receptor Antagonists Are Mediated by an Enhancement of GABAergic Synaptic Transmission via a Presynaptic CB1 Receptor Mechanism

Cells, 2022
In this study, we investigated the cross-talk between mGlu1 and CB1 receptors in modulating GABA hippocampal output in whole-cell voltage clamp recordings in rat hippocampal acute slices, in organotypic hippocampal slices exposed to oxygen and glucose ...
Elisa Landucci, Rolando Berlinguer-Palmini, Gilda Baccini, Francesca Boscia, Elisabetta Gerace, Guido Mannaioni, Domenico E. Pellegrini-Giampietro   +6 more
doaj   +1 more source

A Fully Soft Sensing Suit With Optimal Sensor Placement for Real‐Time Motion Tracking

Advanced Intelligent Systems, EarlyView.
A fully soft, skin‐conformable sensing suit integrating stretchable sensors, liquid metal wiring, and soft electrodes was developed using direct ink writing, with sensor placement optimized through an automated algorithmic pipeline. This system enables accurate and unobtrusive real‐time motion tracking, providing a scalable, material‐based solution to ...
Jinhyeok Oh, Joonbum Bae
wiley   +1 more source

WIN55,212-2, a Dual Modulator of Cannabinoid Receptors and G Protein-Coupled Inward Rectifier Potassium Channels

Biomedicines, 2021
The coupling of cannabinoid receptors, CB1 and CB2, to G protein-coupled inward rectifier potassium channels, GIRK1 and GIRK2, modulates neuronal excitability in the human brain.
Dongchen An, Steve Peigneur, Jan Tytgat
doaj   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Distinct activation mechanisms regulate subtype selectivity of Cannabinoid receptors

Communications Biology, 2023
Design of cannabinergic subtype selective ligands is challenging because of high sequence and structural similarities of cannabinoid receptors (CB1 and CB2).
Soumajit Dutta, Diwakar Shukla
doaj   +1 more source

Interkingdom Interactions in the Gut: Ecological Mechanisms, Homeostasis, and Therapeutic Modulation

Gut Medicine, EarlyView.
ABSTRACT The gut microbiota constitutes a highly complex and dynamic ecosystem that profoundly influences host physiology, metabolism, and immunity. This review provides an integrative overview of the mechanisms through which gut microorganisms—particularly bacteria and fungi—interact with host cells and with each other to maintain intestinal ...
Rui‐Qi Wei, Xin‐Wei Sun, Hao‐Jie Huang, Yu‐Zhi Zhao, Shuang‐Jiang Liu, Chang Liu   +5 more
wiley   +1 more source

Holocene sea‐level and environmental changes on the Isle of Mull, Scotland

Journal of Quaternary Science, EarlyView.
ABSTRACT Sea‐level and coastal changes are reconstructed on the Isle of Mull, western Scotland, from 10 988 to 10 507 cal BP to the present. This research has produced the first SLIP for the Isle of Mull. A multiproxy approach including pollen, spore, foraminifera and diatom analyses reveals palaeoenvironmental changes from two coastal sites.
Katherine A. Selby, Jane Wheeler, William E. N. Austin, Heather Austin, Tom Hill, Sarah L. Bradley, Sally Derrett   +6 more
wiley   +1 more source

Activation of cannabinoid type 2 (CB2) receptors promotes the maintenance of redox homeostasis and protects against oxidative distress in the Neotropical freshwater fish matrinxã Brycon amazonicus (Characiformes: Bryconidae) [PDF]

Neotropical Ichthyology
Recent evidence indicates significant interaction of cannabinoid receptors (CB1 and CB2) with redox mechanisms. This study investigated the effects of the cannabinoid agonists WIN 55,212-2 (CB1+CB2) and HU-308 (CB2) on oxidative biomarkers in the liver ...
Suzana Luisa Alves Fernandes, Yan Costa Gonçalves, Francisco Tadeu Rantin, Ana Lúcia Kalinin, Diana Amaral Monteiro   +4 more
doaj   +1 more source

Off-target pharmacological profiling of synthetic cannabinoid receptor agonists including AMB-FUBINACA, CUMYL-PINACA, PB-22, and XLR-11

Frontiers in Psychiatry, 2022
IntroductionSynthetic cannabinoid receptor agonists (SCRAs) are a diverse class of new psychoactive substances that have been associated with multiple instances and types of toxicity. Some SCRAs appear to carry a greater toxicological burden than others,
Richard C. Kevin, Richard C. Kevin, Elizabeth A. Cairns, Elizabeth A. Cairns, Rochelle Boyd, Rochelle Boyd, Jonathon C. Arnold, Jonathon C. Arnold, Michael T. Bowen, Michael T. Bowen, Iain S. McGregor, Iain S. McGregor, Samuel D. Banister, Samuel D. Banister   +13 more
doaj   +1 more source

Traditional Chinese Medicine as an Integrative Adjunct in Oncology Perioperative Practice: Analgesia, Immune Modulation, and Translational Challenges

Medicine Bulletin, EarlyView.
ABSTRACT Traditional Chinese medicine (TCM), including herbal analgesic adjuvants and acupuncture‐based interventions, has gained increasing attention as an integrative strategy for perioperative pain management in oncology. Bioactive phytochemicals—such as terpenoids, flavonoids, alkaloids, and polyphenols—exert multimodal pharmacological effects ...
Yuqin Tang, Zheng Luo, Xu Zhao, Yongqiang Zhang, Mingyang Sun, Jiaqiang Zhang   +5 more
wiley   +1 more source