Results 21 to 30 of about 25,158 (238)
The CB1 Receptor as the Cornerstone of Exostasis [PDF]
Neuron, 2017 The type-1 cannabinoid receptor (CB1) is the main effector of the endocannabinoid system (ECS), which is involved in most brain and body functions. In this Perspective, we provide evidence indicating that CB1 receptor functions are key determinants of bodily coordinated exostatic processes.
Pier Vincenzo Piazza +2 more
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Modulation of pilocarpine-induced seizures by cannabinoid receptor 1. [PDF]
PLoS ONE, 2014 Administration of the muscarinic agonist pilocarpine is commonly used to induce seizures in rodents for the study of epilepsy. Activation of muscarinic receptors has been previously shown to increase the production of endocannabinoids in the brain ...
Rebecca L Kow +5 more
doaj +1 more source
Frontiers in Immunology, 2023 Cannabinoid (CB) receptors (CB1 and CB2) are expressed on cancer cells and their expression influences carcinogenesis in various tumor entities. Cells of the tumor microenvironment (TME) also express CB receptors, however, their role in tumor development
Arailym Sarsembayeva +12 more
doaj +1 more source
Internalization and Recycling of the CB1 Cannabinoid Receptor [PDF]
Journal of Neurochemistry, 1999 Abstract : Tolerance develops rapidly to cannabis, cannabinoids, and related drugs acting at the CB1 cannabinoid receptor. However, little is known about what happens to the receptor as tolerance is developing. In this study, we have found that CB1 receptors are rapidly internalized following agonist binding and receptor activation ...
C, Hsieh +3 more
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Beni-Suef University Journal of Basic and Applied Sciences, 2021 Background The endocannabinoid CB1 receptor is known to have protective effects in kidney disease. The aim of the present study is to evaluate the potential agonistic and antagonistic actions and to determine the renoprotective potential of CB1 receptors
Jayarami Reddy Medapati +5 more
doaj +1 more source
Frontiers in Neuroanatomy, 2022 The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate Gi/o proteins in the medial ...
Leyre Echeazarra +27 more
doaj +1 more source
Voltage dependence of the cannabinoid CB1 receptor
Frontiers in Pharmacology, 2022 Cannabinoids produce their characteristic effects mainly by binding to two types of G-protein coupled receptors (GPCRs), the CB1 and CB2 cannabinoid receptors. The CB1 receptor is the main cannabinoid receptor in the central nervous system, and it participates in many brain functions.
Esty Goldberger +2 more
openaire +3 more sources
Probing the Interaction of SR141716A with the CB1 Receptor [PDF]
Journal of Biological Chemistry, 2012 SR141716A binds selectively to the brain cannabinoid (CB1) receptor and exhibits a potent inverse agonist/antagonist activity. Although SR141716A, also known as rimonabant, has been withdrawn from the market due to severe side effects, there remains interest in some of its many potential medical applications.
Joong-Youn, Shim +2 more
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The Interplay between the Immune and the Endocannabinoid Systems in Cancer
Cells, 2021 The therapeutic potential of Cannabis sativa has been recognized since ancient times. Phytocannabinoids, endocannabinoids and synthetic cannabinoids activate two major G protein-coupled receptors, subtype 1 and 2 (CB1 and CB2).
Mariantonia Braile +5 more
doaj +1 more source
Differential β-arrestin2 requirements for constitutive and agonist-induced internalization of the CB1 cannabinoid receptor [PDF]
, 2013 CB1 cannabinoid receptor (CB1R) undergoes both constitutive and agonist-induced internalization, but the underlying mechanisms of these processes and the role of beta-arrestins in the regulation of CB1R function are not completely understood.
Boros, Eszter +7 more
core +1 more source