Results 31 to 40 of about 25,158 (238)

High-resolution Immunoelectron Microscopy Techniques for Revealing Distinct Subcellular Type 1 Cannabinoid Receptor Domains in Brain

Bio-Protocol, 2019
Activation of type 1 cannabinoid (CB1) receptors by endogenous, exogenous (cannabis derivatives) or synthetic cannabinoids (i.e., CP 55.940, Win-2) has a wide variety of behavioral effects due to the presence of CB1 receptors in the brain.
Nagore Puente, Itziar Bonilla-Del Río, Svein Achicallende, Patrick Nahirney, Pedro Grandes   +4 more
doaj   +1 more source

Cannabinoid type 1 and type 2 receptor antagonists prevent attenuation of serotonin-induced reflex apneas by dronabinol in Sprague-Dawley rats. [PDF]

PLoS ONE, 2014
The prevalence of obstructive sleep apnea (OSA) in Americans is 9% and increasing. Increased afferent vagal activation may predispose to OSA by reducing upper airway muscle activation/patency and disrupting respiratory rhythmogenesis.
Michael W Calik, David W Carley
doaj   +1 more source

CB1 cannabinoid receptor expression in the striatum: Association with corticostriatal circuits and developmental regulation

Frontiers in Pharmacology, 2012
Corticostriatal circuits mediate various aspects of goal-directed behavior and are critically important for basal ganglia-related disorders. Activity in these circuits is regulated by the endocannabinoid system via stimulation of CB1 cannabinoid ...
Vincent eVan Waes, Joel eBeverley, Homayoun eSiman, Kuei Y. eTseng, Heinz eSteiner   +4 more
doaj   +1 more source

Signal transduction of the CB1 cannabinoid receptor [PDF]

Journal of Molecular Endocrinology, 2009
The CB1 cannabinoid receptor (CB1R) is the major cannabinoid receptor in neuronal cells and the brain, but it also occurs in endocrine cells and other peripheral tissues. CB1R is a member of the superfamily of G-protein-coupled receptors (GPCRs), which are characterized by seven transmembrane helices.
Gábor, Turu, László, Hunyady
openaire   +2 more sources

Cannabinoid CB1 receptor [PDF]

Science-Business eXchange, 2008
  +12 more sources

Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice

Cell Death and Disease, 2022
Cannabinoids are known to modulate oligodendrogenesis and developmental CNS myelination. However, the cell-autonomous action of these compounds on oligodendroglial cells in vivo, and the molecular mechanisms underlying these effects have not yet been ...
Aníbal Sánchez-de la Torre, Tania Aguado, Alba Huerga-Gómez, Silvia Santamaría, Antonietta Gentile, Juan Carlos Chara, Carlos Matute, Krisztina Monory, Susana Mato, Manuel Guzmán, Beat Lutz, Ismael Galve-Roperh, Javier Palazuelos   +12 more
doaj   +1 more source

Lack of the Transient Receptor Potential Vanilloid 1 Shifts Cannabinoid-Dependent Excitatory Synaptic Plasticity in the Dentate Gyrus of the Mouse Brain Hippocampus

Frontiers in Neuroanatomy, 2021
The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term depression (LTD) of the excitatory ...
Jon Egaña-Huguet, Jon Egaña-Huguet, Miquel Saumell-Esnaola, Miquel Saumell-Esnaola, Svein Achicallende, Svein Achicallende, Edgar Soria-Gomez, Edgar Soria-Gomez, Edgar Soria-Gomez, Itziar Bonilla-Del Río, Itziar Bonilla-Del Río, Gontzal García del Caño, Gontzal García del Caño, Sergio Barrondo, Sergio Barrondo, Joan Sallés, Joan Sallés, Inmaculada Gerrikagoitia, Inmaculada Gerrikagoitia, Nagore Puente, Nagore Puente, Izaskun Elezgarai, Izaskun Elezgarai, Pedro Grandes, Pedro Grandes, Pedro Grandes   +25 more
doaj   +1 more source

Cannabinoid receptors distribution in mouse cortical plasma membrane compartments

Molecular Brain, 2021
The type 1 and type 2 cannabinoid receptors (CB1 and CB2 receptors) are class A G protein-coupled receptors (GPCRs) that are activated by endogenous lipids called endocannabinoids to modulate neuronal excitability and synaptic transmission in neurons ...
Hajar Miranzadeh Mahabadi, Haseeb Bhatti, Robert B. Laprairie, Changiz Taghibiglou   +3 more
doaj   +1 more source

Hippocampal CB1 Receptors Control Incidental Associations [PDF]

Neuron, 2018
By priming brain circuits, associations between low-salience stimuli often guide future behavioral choices through a process known as mediated or inferred learning. However, the precise neurobiological mechanisms of these incidental associations are largely unknown.
Busquets-Garcia, Arnau, Oliveira da Cruz, José F., Terral, Geoffrey, Zottola, Antonio C. Pagano, Soria-Gomez, Edgar, Contini, Andrea, Martin, Hugo, Redon, Bastien, Varilh, Marjorie, Ioannidou, Christina, Drago, Filippo, Massa, Federico, Fioramonti, Xavier, Trifilieff, Pierre, Ferreira, Guillaume, Marsicano, Giovanni   +15 more
openaire   +5 more sources

Inhibition of GABAergic Neurons and Excitation of Glutamatergic Neurons in the Ventrolateral Periaqueductal Gray Participate in Electroacupuncture Analgesia Mediated by Cannabinoid Receptor

Frontiers in Neuroscience, 2019
Although electroacupuncture (EA) has become a worldwide practice, little is understood about its precise target in the central nervous system (CNS) and the cell type-specific analgesia mechanism.
He Zhu, He Zhu, Hong-Chun Xiang, Hong-Ping Li, Li-Xue Lin, Xue-Fei Hu, Hong Zhang, Wang-Yang Meng, Lu Liu, Chao Chen, Yang Shu, Ru-Yue Zhang, Pei Zhang, Jun-Qiang Si, Man Li   +14 more
doaj   +1 more source