Results 81 to 90 of about 19,856 (171)

Cannabinoid CB1 receptor (CNR1) [PDF]

Science-Business eXchange, 2009
  +7 more sources

Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats

BMC Urology, 2017
Background This study investigated changes in the expression of cannabinoid (CB) receptors and the effects of CB1 and CB2 agonists on detrusor overactivity (DO) associated with bladder outlet obstruction (BOO) in rats.
Sung Dae Kim, Kang Jun Cho, Joon Chul Kim   +2 more
doaj   +1 more source

Cytotoxicity Potency of Cannabinoids Is by Serum Supplementation: Implications for In Vitro Cancer Studies

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Fetal calf serum (FCS) is a key supplement in cell culture, providing nutrients, and growth factors that support cancer cell proliferation. Studies suggest that compound cytotoxicity profiles in vitro vary depending on FCS concentration in culture medium. The study aimed to examine how extracellular conditions influence the in vitro
Sanele Priscillia Mathibela, Maphuti Tebogo Lebelo, Vanessa Steenkamp   +2 more
wiley   +1 more source

Identification and Structural Elucidation of a New Synthetic Cannabinoid, MDMB‐5′Br‐PINACA, in Seized Herbal Materials

Drug Testing and Analysis, Volume 18, Issue 3, Page 334-340, March 2026.
MDMB‐5Br‐PINACA, a novel synthetic cannabinoid, was identified and structurally characterized in seized herbal products using GC‐MS, LC‐HRMS, and NMR. The discovery underscores ongoing diversification of SCs and the need for vigilant surveillance.
Alexandre Barcia de Godoi, Lucas André Zeoly, Rafael Lanaro, Ingrid Simões Oliveira, Mariana Cepollaro Diana, Mauricio Yonamine, Jose Luiz Costa   +6 more
wiley   +1 more source

Endocannabinoids and Schizophrenia

Pharmaceuticals, 2010
The endocannabinoids anandamide and 2-arachydonoylglycerol (2-AG) are lipids naturally derived from membrane precursors which bind cannabinoid receptors (CB1, CB2). This endocannabinoid system is disturbed in schizophrenia.
Stéphane Potvin, Lahcen Ait Bentaleb, Emmanuel Stip, Joëlle Desfoss��s   +3 more
doaj   +1 more source

The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl

Developmental Dynamics, Volume 255, Issue 3, Page 321-339, March 2026.
Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino, Sarah E. Walker, Gaynor E. Spencer, Robert Carlone   +3 more
wiley   +1 more source

Cannabinoid CB1 Receptors Are Localized in Striated Muscle Mitochondria and Regulate Mitochondrial Respiration

Frontiers in Physiology, 2016
The cannabinoid type 1 (CB1) receptor is widely distributed in the brain and peripheral organs where it regulates cellular functions and metabolism. In the brain, CB1 is mainly localized on presynaptic axon terminals but is also found on mitochondria ...
Juan Mendizabal-Zubiaga, Juan Mendizabal-Zubiaga, Su Melser, Su Melser, Giovanni Bénard, Almudena Ramos, Almudena Ramos, Giovanni Bénard, Leire Reguero, Leire Reguero, Sergio Arrabal, Izaskun Elezgarai, Izaskun Elezgarai, Inmaculada Gerrikagoitia, Inmaculada Gerrikagoitia, Juan Suárez, Fernando Rodríguez de Fonseca, Nagore Puente, Nagore Puente, Giovanni Marsicano, Giovanni Marsicano, Pedro Grandes, Pedro Grandes, Pedro Grandes   +23 more
doaj   +1 more source

Suicide attempt and paranoia persisting for 28 days following heavy delta‐9‐tetrahydrocannabinolic acid and tetrahydrocannabinol use: A case report

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 1, March 2026.
Abstract Background Cannabis contains various cannabinoids, with Δ9‐tetrahydrocannabinol (Δ9‐THC) being the primary psychoactive compound. A non‐psychoactive precursor called Δ9‐tetrahydrocannabinolic acid (THC‐A) is converted to Δ9‐THC slowly over time or rapidly when heated. Cannabis use is linked to psychotic outcomes, with increased risk associated
Daniel Greer, Prithula Dey, Caitlin E. Kulig   +2 more
wiley   +1 more source

Somatic and terminal CB1 receptors are differentially coupled to voltage-gated sodium channels in neocortical neurons. [PDF]

Cell Rep, 2023
Steiger LJ, Tsintsadze T, Mattheisen GB, Smith SM.   +3 more
europepmc   +1 more source

NQO1‐Responsive Prodrug for in Cellulo Release of Cytochalasin B as Cancer Cell‐Targeted Migrastatic

Small, Volume 22, Issue 16, 17 March 2026.
The design, synthesis, biochemical, and cell biological evaluation of the NQO1‐targeted prodrug BQTML‐CB is reported. BQTML‐CB selectively releases cytochalasin B upon activation by the quinone‐oxidoreductase NQO1 associated with invasiveness of cancer cells, representing a novel approach to improve cancer selectivity and reduce immunosuppressive ...
Mervic D. Kagho, Katharina Schmidt, Christopher Lambert, Lili Jia, Vignesh Venkatakrishnan, Luisa Mehr, Johan Bylund, Klemens Rottner, Marc Stadler, Theresia E. B. Stradal, Philipp Klahn   +10 more
wiley   +1 more source