Results 61 to 70 of about 3,492 (143)

Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia–initiating CBFB::MYH11 oncofusion protein

The Journal of Clinical Investigation
Several canonical translocations produce oncofusion genes that can initiate acute myeloid leukemia (AML). Although each translocation is associated with unique features, the mechanisms responsible remain unclear.
Ryan B. Day, Julia A. Hickman, Ziheng Xu, Casey D.S. Katerndahl, Francesca Ferraro, Sai Mukund Ramakrishnan, Petra Erdmann-Gilmore, Robert W. Sprung, Yiling Mi, R. Reid Townsend, Christopher A. Miller, Timothy J. Ley   +11 more
doaj   +1 more source

ACUTE MYELOID LEUKEMIA WITH CBFB:MYH11 FUSION AND PRESENCE OF ABERRANT MAST CELLS: A CASE REPORT

Hematology, Transfusion and Cell Therapy
Objectives: Acute myeloid leukemia (AML) with CBFB::MYH11 fusion is characterized by the clonal proliferation of monocytic and neutrophilic myeloid precursors and typically an abnormal eosinophilic component.
JL Eiroff, LS Abreu, CC Pieri, IM Santos-Pirath, CC Cardoso, HZ Costa, JPB Soares, G Steffenello, AOM Wagner, MC Santos-Silva   +9 more
doaj   +1 more source

Venetoclax plus azacitidine, low‐dose cytarabine, aclarubicin, and G‐CSF (VA‐CAG regimen) for newly diagnosed young patients with acute myeloid leukemia: A prospective, multicenter, single‐arm Phase II clinical trial

HemaSphere, Volume 10, Issue 8, August 2026.
Abstract We conducted a prospective, multicenter, Phase II study to evaluate the safety and efficacy of venetoclax/azacitidine/low‐dose cytarabine/aclarubicin/granulocyte colony‐stimulating factor (G‐CSF) (VA‐CAG) in young patients with newly diagnosed acute myeloid leukemia (ND‐AML). The VA‐CAG regimen included venetoclax (100 mg/day, Days 1–2; 200 mg,
Xiaoping Li, Qiurong Zhang, Xiaoyan Li, Lin Liu, Yonglin Shen, Yu Li, Lihui Peng, Chaoyang Zhou, Chie Qiu, Zhongtao Yuan, Shiqian Hou, Youcheng Wang, Lihua Zhang, Jingqiong Li, Liang Zhao, Qiuyuan Tang, Zucong Chen, Jing Feng, Xuejuan Zhang, Guoxiu Bao, Kui Zhang, Renpeng Zhang, Shiqi Li, Yingnian Chen, Jianhua Rao, Yancheng Dong, Dingsong Zhang, Yueyuan Wang, Aifang Li, Xi Ye, Lei Lei, Jiao Chen, Sufen Xu, Yanling Jin, Chaoen Zheng, Yang Liang, Sanbin Wang   +36 more
wiley   +1 more source

Measurable residual disease by multicolor flow cytometry in acute myeloid leukemia: A comparison of peripheral blood and bone marrow

Cytometry Part B: Clinical Cytometry, Volume 110, Issue 4, Page 259-265, July 2026.
Abstract Measurable residual disease (MRD) monitoring by multiparameter flow cytometry (MFC) is well established in bone marrow (BM) samples for acute myeloid leukemia (AML), but its use in peripheral blood (PB) remains less developed. We adapted a semi‐automated and well validated MFC‐MRD assay, originally developed for BM, to PB aiming to evaluate ...
Jonas Schadt, Malte von Bonin, Uta Oelschlägel, Christoph Röllig, Christian Thiede, Leo Ruhnke, Martin Bornhäuser, Sebastian Brenner, Maximilian Alexander Röhnert   +8 more
wiley   +1 more source

Venetoclax‐Integrated Conditioning Strategies Prior to Allogeneic Hematopoietic Stem Cell Transplantation in Myeloid Neoplasms: A Scoping Review of Emerging Evidence

European Journal of Haematology, Volume 117, Issue 1, Page 117-131, July 2026.
ABSTRACT Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) remains the only potentially curative therapy for many patients with high‐risk myeloid neoplasms, yet relapse and transplant‐related toxicity continue to limit durable benefit.
Mohammed Abdulgayoom, Amaal Gulied, Awni Alshurafa, Shehab F. Mohamed, Mohamed A. Yassin, Afraa Fadul   +5 more
wiley   +1 more source

Concurrent BCR‐ABL1 and core binding factor beta rearrangement in de novo acute myeloid leukemia: A case report and review of literature

eJHaem
A distinct subset of acute myeloid leukemia (AML) is characterized by the presence of the Philadelphia chromosome (Ph+), due to reciprocal translocation t(9;22)(q34;q11.2).
Brittany Salter, Sarah Ge, Amy Tam, Suzanne Demczuk, Darci Butcher, Elizabeth McCready, Dina Khalaf   +6 more
doaj   +1 more source

LEUCEMIA MIELOIDE AGUDA MONOCÍTICA FUSÃO CBFB::MHY11 COM 4 RECIDIVAS, RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Introdução: Leucemia mieloide aguda (LMA) com inv(16)/t(16;16) resultando na transcrição de fusão CBFB::MYH11, pertence à categoria de risco favorável.
LZ Caputo, CE Gomes, DZ Caputo, RMA Passos, M Jorge, EX Souto, LLM Perobelli   +6 more
doaj   +1 more source

Marked Bone Marrow Eosinophilia Post‐Azacitidine + Ivosidenib Treatment for Acute Myeloid Leukemia

International Journal of Laboratory Hematology, Volume 48, Issue 5, Page 921-923, October 2026.
Christopher Liwski, Curtis Marcoux, David M. Conrad   +2 more
wiley   +1 more source

PPP1R7 Is a Novel Translocation Partner of CBFB via t(2;16)(q37;q22) in Acute Myeloid Leukemia

, 2022
In a subset of acute myeloid leukemia (AML) cases, the core binding factor beta subunit gene (CBFB) was rearranged via inv(16)(p13.1q22) or t(16;16)(p13.1;q22), in which the smooth muscle myosin heavy chain 11 gene (MYH11) was the partner (CBFB::MYH11 ...
Borthakur, Gautam, You, M. James, Khoury, Joseph D., Wang, Wei, C. Yin, Hannah C. Beird, Cheng, Xueqian, Issa, Ghayas C., C. Cameron Yin, Beird, Hannah C., Zhenya Tang, Fang, Hong, Gokce A. Toruner, Khoury, Joseph D, Wang, Lulu, Toruner, Gokce A., Guilin Tang, Joseph Khoury, Issa, Ghayas C, Gokce Toruner, Ghayas Issa, Yin, C. Cameron, Ghayas C. Issa, Wei Wang, Yin, C Cameron, M. You, Gautam Borthakur, Tang, Guilin, L. Medeiros, Beird, Hannah C, Hong Fang, Hannah Beird, Medeiros, L Jeffrey, Xueqian Cheng, Joseph D. Khoury, Medeiros, L. Jeffrey, M. James You, Guang Peng, Peng, Guang, Tang, Zhenya, L. Jeffrey Medeiros, Toruner, Gokce A, You, M James, Lulu Wang   +43 more
core   +1 more source

Nested-PCR vs. RT-qPCR: A Sensitivity Comparison in the Detection of Genetic Alterations in Patients with Acute Leukemias

DNA
The detection of genetic alterations in patients with acute leukemias is essential for the targeting of more specific and effective therapies. Therefore, the aim of this study was to compare the sensitivity of Nested-PCR and RT-qPCR techniques in the ...
Flávia Melo Cunha de Pinho Pessoa, Marcelo Braga de Oliveira, Igor Valentim Barreto, Anna Karolyna da Costa Machado, Deivide Sousa de Oliveira, Rodrigo Monteiro Ribeiro, Jaira Costa Medeiros, Aurélia da Rocha Maciel, Fabiana Aguiar Carneiro Silva, Lívia Andrade Gurgel, Kaira Mara Cordeiro de Albuquerque, Germison Silva Lopes, Ricardo Parente Garcia Vieira, Jussara Alencar Arraes, Meton Soares de Alencar Filho, André Salim Khayat, Maria Elisabete Amaral de Moraes, Manoel Odorico de Moraes Filho, Caroline Aquino Moreira-Nunes   +18 more
doaj   +1 more source