Results 71 to 80 of about 3,492 (143)

Improved survival with fludarabine‐based therapies in mixed phenotype acute leukaemia: A population‐based study using the WHO 2022 classification

British Journal of Haematology, Volume 208, Issue 6, Page 2104-2112, June 2026.
Summary Mixed phenotype acute leukaemia (MPAL) is a rare subtype of acute leukaemia possessing significant therapeutic challenges, as no standardized, evidence‐based treatment regimen has been defined. In this nationwide study, we aimed to assess the effect of an acute lymphoid leukaemia (ALL)‐like regimen; an acute myeloid leukaemia (AML)‐like regimen;
Lisa‐Maj Christensen, Mikkel Runason Simonsen, Jonas Faartoft Jensen, Daniel Tuyet Kristensen, Karen Dybkær, Kirsten Grønbæk, Tarec Christoffer El‐Galaly, Marianne Schmidt Ettrup, Hans Beier Ommen, Anne Louise Tølbøll Sørensen, Dennis Lund Hansen, Marianne Tang Severinsen   +11 more
wiley   +1 more source

Relevance of presenting white blood cell count and kinetics of molecular remission in the prognosis of acute myeloid leukemia with CBFbeta/MYH11 rearrangement

Haematologica, 2000
BACKGROUND AND OBJECTIVES: The detection of CBFbeta/MYH11 transcripts by RT-PCR has became a valuable and widely used technique in the accurate cytogenetic and molecular classification of acute myeloid leukemia (AML), but the clinical value of RT-PCR for
G Martin, E Barragan, P Bolufer, C Chillon, R Garcia-Sanz, T Gomez, S Brunet, M Gonzalez, MA Sanz   +8 more
doaj  

KIT with D816 mutations cooperates with CBFB-MYH11 for leukemogenesis in mice

, 2012
KIT mutations are the most common secondary mutations in inv(16) acute myeloid leukemia (AML) patients and are associated with poor prognosis. It is therefore important to verify that KIT mutations cooperate with CBFB-MYH11, the fusion gene generated by ...
D. Gary Gilliland, Shelley Hoogstraten-Miller, Lemlem Alemu, P. Paul Liu, Martha Kirby, Ling Zhao, Stacie Anderson, Jan J. Melenhorst, Maggie Kench, Lauren Brinster, Yasuhiko Kamikubo   +10 more
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Diagnóstico de Sarcoma Mieloide com Fusão do gene CBFB-MYH11 da inv(16) em Líquido Pleural: Um Relato de Caso [PDF]

, 2021
Trabalho de Conclusão (Residência). Universidade Federal de Santa Catarina. Comissão de Residência Multiprofissional e Uniprofissional em Saúde. Residência Integrada Multiprofissional em Saúde.RESUMO: Objetivo: Este relato teve como objetivo apresentar ...
De Azevedo, Larissa Bonfiglio
core  

FLT3 Length Mutations as Marker for Follow-Up Studies in Acute Myeloid Leukaemia [PDF]

, 2004
Length mutations within the FLT3 gene (FLT3-LM) can be found in 23% of acute myeloid leukaemia (AML) and thus are the most frequent mutations in AML. FLT3-LM are highly correlated with AML with normal karyotype and other cytogenetic aberrations of the ...
Kern, Wolfgang, Schnittger, Susanne, Haferlach, Torsten, Hiddemann, Wolfgang, Schoch, Claudia   +4 more
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RELATO DE CASO: APRESENTAÇÃO CLÍNICA E LABORATORIAL ATÍPICA DE LEUCEMIA MIELOIDE AGUDA ASSOCIADA A INVERSÃO DO CROMOSSOMO 16

Hematology, Transfusion and Cell Therapy
Introdução: Leucemia mieloide aguda (LMA) é um grupo heterogêneo de neoplasias mieloides caracterizado pela proliferação descontrolada de células hematopoiéticas clonais, resultando em hematopoiese ineficaz e citopenias potencialmente fatais.
PM Resende, AC Meireles, EX Souto, GF Perini, D Borri, EDRP Velloso, FA Sousa, LC Bento, E Santos-Junior, NS Bacal   +9 more
doaj   +1 more source

Prognostic Impact of Minimal Residual Disease inCBFB-MYH11–Positive Acute Myeloid Leukemia

, 2010
Purpose To evaluate the prognostic impact of minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) expressing the CBFB-MYH11 fusion transcript. Patients and Methods Quantitative reverse transcriptase polymerase chain reaction (PCR)
Juan Du, Mathias Rummel, Richard F. Schlenk, Stefan Fröhling, Arnold Ganser, Lars Bullinger, David Nachbaur, Jürgen Krauter, Claudia Scholl, Hans-Günter Derigs, Karina Eiwen, Hartmut Döhner, Peter Reimer, Andrea Corbacioglu, Konstanze Döhner   +14 more
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CBFB Break-Apart FISH Testing: An Analysis of 1629 AML Cases with a Focus on Atypical Findings and Their Implications in Clinical Diagnosis and Management

, 2021
Fluorescence in situ hybridization (FISH) is a confirmatory test to establish a diagnosis of inv(16)/t(16;16) AML. However, incidental findings and their clinical diagnostic implication have not been systemically studied.
Hong Fang, C. Cameron Yin, Richard K. Yang, Zhenya Tang, Sa A. Wang, Beenu Thakral, Gokce A. Toruner, Shujuan Liu, Joseph D. Khoury, Guilin Tang, Roberto N. Miranda, Guang Peng, Ghayas C. Issa, Keyur P. Patel, Wei Wang, L. Jeffrey Medeiros, Gautam Borthakur, Andrés E. Quesada, Lulu Wang   +18 more
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Detection of CBFB/MYH11 transcripts in patients with inversion and other abnormalities of chromosome 16 at presentation and remission

The pericentric inversion of chromosome 16 [inv(16)(p13q22)] and t(16;16)(p13;q22) are chromosomal rearrangements frequently associated with AML FAB type M4Eo resulting in the production of a fusion gene CBFB/MYH11.
Johnson PR, Saunders MJ, Tobal K, Liu Yin JA, Harrison CJ   +4 more
core   +5 more sources

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source