Results 81 to 90 of about 3,492 (143)

Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias

, 2010
Early relapse detection in acute myeloid leukemia is possible using standardized real-time quantitative polymerase chain reaction (RQ-PCR) protocols.
Ommen, Hans Beier, Schnittger, Susanne, Hasle, Henrik, Ommen, Ingrid Beier, Ostergaard, Mette, Hokland, Peter, Grimwade, David, Jovanovic, Jelena V.   +7 more
core   +1 more source

The incidence of submicroscopic deletions in reciprocal translocations is similar in acute myeloid leukemia, BCR-ABL positive acute lymphoblastic leukemia, and chronic myeloid leukemia

Haematologica, 2005
We compared the incidence of submicroscopic deletions accompanying balanced translocations using interphase fluorescence in situ hybridization (FISH) in 245 patients with chronic myeloid leukemia (CML), 79 patients with acute lymphoblastic leukemia (ALL)
U Bacher, S Schnittger, W Kern, W Hiddemann, T Haferlach, C Schoch   +5 more
doaj  

Characterization of leukemia progression in the Cbfb-MYH11 knockin mice by single cell RNA sequencing. [PDF]

Leukemia, 2023
Diemer JL, Yu K, Kelly M, Zhen T, Anderson S, Lopez G, Liu P.   +6 more
europepmc   +1 more source

Abstract B079: Small-molecule inhibition of CBFB::MYH11 in chemoresistant inv(16) acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy and the most common form of acute leukemia in adults. Although standard induction therapy with cytarabine and an anthracycline achieves high remission rates, it is frequently associated
Bon Q. Trinh, Francine Garret-Balkerman, Hien La, Katelyn Do, Nazifar Azam, A S M Walliulah, Barbara Dziegielewska, Ly P. Vu, Nicholas Nguyen, Nam Chu, Jeffrey W. Craig, Malena Nong, Misha Padigala, Anna Bookstaver, Joshua Pei, Thuy-An Nguyen, Hong Zhu   +16 more
core   +1 more source

Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11

, 2005
Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. Landrette SF, Kuo YH, Hensen K, Khosrovani B, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH.
Van de Ven, WJM, Barjesteh van Waalwijk, S, Kuo, YH, Delwel, R., Perrat, PN, Castilla, L.H., Landrette, SF, Hensen, K, Landrette, S.F., van de Ven, W.J., Hensen, K., Perrat, P.N., Delwel, Ruud, van Waalwijk van Doorn-Khosrovani, S.B., Castilla, LH, Kuo, Y.H.   +15 more
core   +1 more source

Detection of inv(16) and t(16;16) by fluorescence in situ hybridization in acute myeloid leukemia M4Eo

Haematologica, 2000
BACKGROUND AND OBJECTIVE: It has been established that cytogenetic findings at the time of diagnosis of acute myeloid leukemia (AML) are powerful prognostic indicators.
JM Hernandez, MB Gonzalez, I Granada, N Gutierrez, C Chillon, F Ramos, JM Ribera, M Gonzalez, E Feliu, J San Miguel   +9 more
doaj  

Application of droplet digital PCR in minimal residual disease monitoring of rare fusion transcripts and mutations in haematological malignancies

Scientific Reports
Leukaemia of various subtypes are driven by distinct chromosomal rearrangement or genetic abnormalities. The leukaemogenic fusion transcripts or genetic mutations serve as molecular markers for minimal residual disease (MRD) monitoring. The current study
Beca B. K. Ip, Anthony T. C. Wong, Janet Hei Yin Law, Chun Hang Au, Shing Yan Ma, James C. S. Chim, Raymond H. S. Liang, Anskar Y. H. Leung, Thomas S. K. Wan, Edmond S. K. Ma   +9 more
doaj   +1 more source

An inv(16)(p13q22) positive acute myeloid leukaemia relapsing as acute precursor B-cell lymphoblastic leukaemia

Haematologica, 2004
We describe a case of a 38-year old male with inv(16)(p13q22) positive acute myeloid leukaemia (AML) with eosinophilia, relapsing after a molecular remission of almost three years. Remarkably, the leukaemia at relapse was identified as a precursor-B-cell
N Boeckx, VH van der Velden, M Boogaerts, A Hagemeijer, P Vandenberghe, JJ van Dongen   +5 more
doaj  

RELATO DE CASO: LEUCEMIA MIELOIDE AGUDA RELACIONADO À TERAPIA DIAGNOSTICADO DURANTE O TRATAMENTO DE LINFOMA LINFOBLÁSTICO T

Hematology, Transfusion and Cell Therapy
Objetivo: Descrever um raro caso de leucemia mieloide aguda (LMA) com inv(16)/CBFB::MYH11 diagnosticada durante o tratamento de um linfoma linfoblástico T e as implicações do histórico prévio de exposição à terapia citotóxica na condução do caso ...
TR Farina, YVS Oliveira, RL Uliano, MFR Dezan, IR Barbosa, LS Lopes, ALBL Marinho   +6 more
doaj   +1 more source

Core binding factor genes and human leukemia

Haematologica, 2002
BACKGROUND: The core binding factor (CBF) transcription complex, consisting of the interacting proteins RUNX1 and CBFb, is essential for normal hematopoiesis.
SM Hart, L Foroni
doaj