Results 111 to 120 of about 97,974 (286)

CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.

, 1999
CCR5 was first characterized as a receptor for MIP-1alpha, MIP-1beta, and RANTES, and was rapidly shown to be the main coreceptor for M-tropic human immunodeficiency virus (HIV)-1 strains and simian immunodeficiency virus (SIV).
Doranz, Benjamin J., Parmentier, Marc, Blanpain, Cédric, Migeotte, Isabelle, Vakili, Jalal, Lee, B., Govaerts, Cédric, Vassart, Gilbert, Doms, Robert W.   +8 more
core  

Chemokines as Markers for Parasite-Induced Inflammation and Tumors

The International Journal of Biological Markers, 2005
Chemokines are a group of small secreted proteins (8–10 kDa) produced and released by a wide variety of cell types. They were originally described as mediators of leukocyte recruitment, which is essential in acute and chronic inflammation. They also play
C. Trakatelli, S. Frydas, M. Hatzistilianou, E. Papadopoulos, I. Simeonidou, A. Founta, D. Paludi, C. Petrarca, M.L. Castellani, N. Papaioannou, V. Salini, P. Conti, D. Kempuraj, J. Vecchiet   +13 more
doaj   +1 more source

Plasma chitotriosidase activity versus CCL18 level for assessing type I Gaucher disease severity: protocol for a systematic review with meta-analysis of individual participant data

Systematic Reviews, 2017
Background Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by deficiency in acid beta-glucosidase. GD exhibits a wide clinical spectrum of disease severity with an unpredictable natural course.
Tatiana Raskovalova, Patrick B. Deegan, Ruby Yang, Elena Pavlova, Jérome Stirnemann, José Labarère, Ari Zimran, Pramod K. Mistry, Marc Berger   +8 more
doaj   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Effect of high glucose concentration on the synthesis of monocyte chemoattractant protein-1 in human peritoneal mesothelial cells: Involvement of protein kinase C [PDF]

, 2001
Human peritoneal mesothelial cells (HMC) contribute to the activation and control of inflammatory processes in the peritoneum by their potential to produce various inflammatory mediators.
Lederer, Stephan R., Sitter, Thomas, Sellmayer, Alois, Mandl-Weber, Sonja, Haslinger, Bettina   +4 more
core   +1 more source

Differential regulation of C-C chemokines during fibroblast-monocyte interactions: adhesion vs. inflammatory cytokine pathways

Mediators of Inflammation, 1998
The cell-to-ce ll interactions during chronic inflammatory diseases likely contribute to leukocyte accumulation leading to increased pathology and organ dys -function.
C. Zickus, S. L. Kunkel, K. Simpson, H. Evanoff, M. Glass, R. M. Strieter, N. W. Lukacs   +6 more
doaj   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

The CC chemokines CCL8, CCL13 and CCL20 are local inflammatory biomarkers of HLA-B27-associated uveitis

, 2019
PURPOSE: To determine the concentrations of the CC chemokines CCL2, CCL7, CCL8, CCL11, CCL13, CCL20, CCL24 and CCL26 in aqueous humour (AH) samples from patients with specific uveitic entities.
Gikandi, Priscilla W., Opdenakker, Ghislain, Struyf, Sofie, Van Damme, Jo, Berghmans, Nele, Al-Obeidan, Saleh A., Abu El-Asrar, Ahmed M.   +6 more
core   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor

, 2004
The promiscuous D6 receptor binds several inflammatory CC chemokines and has been recently proposed to act as a chemokinescavenging decoy receptor. The present study was designed to better characterize the spectrum of CC chemokines scavenged by D6 ...
VULCANO M, MANTOVANI A., GOBBI M, LOCATI M, SOZZANI, Silvano, HARIBABU B, SIRONI M, VECCHI A, VAN DAMME J, BONECCHI R, FRA, Annamaria, GALLIERA E   +11 more
core   +2 more sources