Animal Models and Experimental Medicine, EarlyView.The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu +10 more
wiley +1 more source
Chemokine Networks in Cutaneous T Cell Lymphoma: Tumor Microenvironment Remodeling and Therapeutic Targets. [PDF]
Curr Issues Mol BiolYu Z +5 more
europepmc +1 more source
SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells
Animal Models and Experimental Medicine, EarlyView.The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang +6 more
wiley +1 more source
Serum CCL1 discriminates infectious and sterile systemic inflammation in sepsis and acute pancreatitis. [PDF]
Sci RepVornhülz M +12 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Directed differentiation of pluripotent stem cells into functional pancreatic β cells have emerged as a promising strategy for the radical treatment of type 1 diabetes, with preclinical and early clinical evidence demonstrating reversal of hyperglycemia and insulin independence.
Zifan Li, Yu Kang, Yuyu Niu
wiley +1 more source
Targeting CXCR1/2 suppresses T<sub>H</sub>2/T<sub>H</sub>17 cell responses and inhibits dual-pathology allergic lung inflammation. [PDF]
J Allergy Clin Immunol GlobHosoki K, Govindhan A, Knight JM, Sur S.
europepmc +1 more source
Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection
Animal Models and Experimental Medicine, EarlyView.A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang +9 more
wiley +1 more source
CCL chemokines as prognostic and immunotherapeutic markers in prostate cancer: a comprehensive analysis. [PDF]
World J Surg OncolBai Y, Liang C, Gu J, Wang L, Yang K.
europepmc +1 more source
Advances and perspectives in animal models of human hepatitis A virus
Animal Models and Experimental Medicine, EarlyView.Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li +3 more
wiley +1 more source
Improvement of Mixed Inflammatory Environment in Nasal Secretions of Diffuse Type 2 Chronic Rhinosinusitis With Nasal Polyps Under Dupilumab. [PDF]
Clin Transl AllergyRyser FS +4 more
europepmc +1 more source