Greater Reductions in Hepatitis B Core-Related Antigen Associated with Switching from Entecavir to Tenofovir Alafenamide Compared with Continued Entecavir Therapy: A Retrospective Observational Study. [PDF]
J Clin MedFukushima M +5 more
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Metabolism and function of hepatitis B virus cccDNA: Implications for the development of cccDNA-targeting antiviral therapeutics [PDF]
Antiviral Research, 2015 Persistent hepatitis B virus (HBV) infection relies on the stable maintenance and proper functioning of a nuclear episomal form of the viral genome called covalently closed circular (ccc) DNA.
Ju-Tao Guo, Haitao Guo
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The Role of cccDNA in HBV Maintenance [PDF]
Viruses, 2017 Chronic hepatitis B virus (HBV) infection continues to be a major health burden worldwide; it can cause various degrees of liver damage and is strongly associated with the development of liver cirrhosis and hepatocellular carcinoma.
Maura Dandri, Lena Allweiss
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Control of cccDNA function in hepatitis B virus infection [PDF]
Journal of Hepatology, 2009 The template of hepatitis B virus (HBV) transcription, the covalently closed circular DNA (cccDNA), plays a key role in the life cycle of the virus and permits the persistence of infection.
Teresa Pollicino +2 more
exaly +7 more sources
Establishment of an inducible HBV stable cell line that expresses cccDNA-dependent epitope-tagged HBeAg for screening of cccDNA modulators [PDF]
Antiviral Research, 2016 Hepatitis B virus (HBV) covalently closed circular (ccc) DNA is essential to the virus life cycle, its elimination during chronic infection is considered critical to a durable therapy but has not been achieved by current antivirals.
Andrea Cuconati +2 more
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Mechanism of Hepatitis B Virus cccDNA Formation [PDF]
Viruses, 2021 Hepatitis B virus (HBV) remains a major medical problem affecting at least 257 million chronically infected patients who are at risk of developing serious, frequently fatal liver diseases. HBV is a small, partially double-stranded DNA virus that goes through an intricate replication cycle in its native cellular environment: human hepatocytes.
Alexander Ploss, Lei Wei, Alexander Plos
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Advanced Strategies for Eliminating the cccDNA of HBV
Digestive Diseases and Sciences, 2017Persistent hepatitis B virus (HBV) infection of hepatocytes is associated with a covalently closed circular DNA (cccDNA) episome. Although serologic hepatitis B surface antigen tests are negative, the presence of cccDNA is obviously increased in HBeAg-positive patients compared with that in HBeAg-negative patients, inactive carriers and patients ...
Miaomiao Zhang
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Hepatitis B virus cccDNA: Formation, regulation and therapeutic potential
Antiviral Research, 2020 Hepatitis B virus (HBV) infection remains a major public health concern worldwide with about 257 million individuals chronically infected. Current therapies can effectively control HBV replication and slow down disease progress, but cannot cure HBV infection.
Yuchen Xia, Haitao Guo
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Discovery of a first-in-class orally available HBV cccDNA inhibitor.
Journal of Hepatology, 2023The persistence of covalently closed circular DNA (cccDNA) in infected hepatocytes is the major barrier preventing viral eradication with existing therapies in patients with chronic hepatitis B. Therapeutic agents that can eliminate cccDNA are urgently needed to achieve viral eradication and thus HBV cure.A phenotypic assay with HBV-infected primary ...
Lisa Sach-Peltason
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A CRISPR-based system to investigate HBV cccDNA biology
Journal of Virology, 2023ABSTRACT Chronic hepatitis B virus (HBV) infections affect over 250 million people worldwide, and over 800,000 are expected to die yearly from complications including cirrhosis and primary hepatocellular carcinoma. While clinically available nucleoside analog-based antiviral therapies inhibit virus production, they cannot cure infections due ...
openaire +2 more sources